Evidence map›Paper›PMID 41361357›Full record

ArticleScientific reports2025

Altered static and dynamic intrinsic brain activity patterns in type 2 diabetic patients.

Yongsheng Liang, Weiyin Vivian Liu, Mingrui Li, Qingzhi Feng, Shouchao Wei, Wenjia Yang, Zihua Guan, Jie Li, Wei Wei, Meilian Li and 1 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Yongsheng LiangDepartment of Radiology, Central People's Hospital of Zhanjiang, Zhanjiang, China.
Weiyin Vivian LiuGE Healthcare, MR Research, Beijing , China.
Mingrui LiDepartment of Radiology, Zhanjiang First Hospital of Traditional Chinese Medicine, Zhanjiang, China.
Qingzhi FengPhysical Examination Centre, Central People's Hospital of Zhanjiang, Zhanjiang, China.
Shouchao WeiZhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Zhanjiang, China.
Wenjia YangDepartment of Clinical Laboratory, Central People's Hospital of Zhanjiang, Zhanjiang, China.
Zihua GuanDepartment of Clinical Laboratory, Central People's Hospital of Zhanjiang, Zhanjiang, China.
Jie LiDepartment of Endocrinology, Central People's Hospital of Zhanjiang, Zhanjiang, China.
Wei WeiGaomi People's Hospital, Weifang, China.
Meilian LiDepartment of Radiology, Central People's Hospital of Zhanjiang, Zhanjiang, China.
Hailing ZhouDepartment of Radiology, Central People's Hospital of Zhanjiang, Zhanjiang, China. ZHL13590049931@163.com.

Funding

The GuangDong Basic and Applied Basic Research Foundation 2021A151515010827The Medical Scientific Research Foundation of Guangdong Province A2024369The Project of Traditional Chinese Medicine Bureau of Guangdong Province 20221444The Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine 20262075The Weifang Health Commission Research Project WFWSJK-2021-296The Zhanjiang Science and Technology Project 2021A05115
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia resulting from insulin secretion and/or resistance. This study investigated intrinsic brain activity alterations using static and dynamic resting-state fMRI metrics in 65 T2DM patients versus 60 healthy controls. We analyzed fractional amplitude of low-frequency fluctuations (fALFF), dynamic fALFF (dfALFF) and dynamic functional stability(DFS). The T2DM group exhibited increased fALFF in the left inferior temporal gyrus and left fusiform gyrus and decreased fALFF in the bilateral precuneus, medial superior frontal gyrus, left inferior parietal lobule, and right supramarginal gyrus when compared with health controls. The T2DM group also showed increased dfALFF in the bilateral precuneus, left inferior parietal lobule, and right middle frontal gyrus. Moreover, the T2DM group exhibited decreased DFS in the bilateral precuneus, supramarginal gyrus, and left middle frontal gyrus, while the left cuneus showed increased dynamic stability. In the T2DM group, montreal cognitive assessment (MoCA) scores correlated negatively with glycated hemoglobin A

Indexed as

BrainDiabetes Mellitus, Type 2AdultAgedBlood GlucoseBrain MappingCase-Control StudiesFemaleGlycated HemoglobinHumansMagnetic Resonance ImagingMaleMiddle AgedBlood GlucoseGlycated HemoglobinDynamic fractional amplitude of low-frequency fluctuationsDynamic stabilityFractional amplitude of low-frequency fluctuationsFunctional magnetic resonance imagingType 2 diabetes

Identifiers

PMID41361357
PMCPMC12789552

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