Evidence map›Paper›PMID 41361351›Full record

ArticleScientific reports2025

Real-world analysis of immune checkpoint inhibitor efficacy and response predictors in patients treated at the CCCMunich

Klara Dorman, Kilian Breitenwieser, Laura Fischer, Danmei Zhang, Victoria Probst, Lena Weiss, Kathrin Heinrich, Wolfgang G Kunz, Julian W Holch, Clemens Gießen-Jung and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Klara DormanDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany. klara.dorman@med.uni-muenchen.de.ORCID 0000-0003-2503-5851
Kilian BreitenwieserDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Laura FischerMax Planck Institute of Psychiatry, Munich, Germany.
Danmei ZhangDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Victoria ProbstDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Lena WeissDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Kathrin HeinrichDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Wolfgang G KunzDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Julian W HolchDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Clemens Gießen-JungDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Michael HaasDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Stefan BoeckDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Michael von Bergwelt-BaildonDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Timotheus LandfarthInstitute for Medical Information Processing, Biometry and Epidemiology, Faculty of Medicine, LMU Munich, Munich, Germany.
Roman HornungInstitute for Medical Information Processing, Biometry and Epidemiology, Faculty of Medicine, LMU Munich, Munich, Germany.
Jozefina CasuscelliDepartment of Urology, University Hospital, LMU Munich, Munich, Germany.
Karin Berger-ThürmelDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Volker HeinemannDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
C Benedikt WestphalenDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Anna ReischerDepartment of Medicine III and Comprehensive Cancer Center, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prediction of response to checkpoint inhibition (ICI) and immune related adverse events (irAEs) remain a challenge in the immunotherapy of solid tumors. To better understand the real-world clinical courses under ICI and identify possible predictive markers for response and irAEs, we retrospectively collected and analysed data from our interdisciplinary CCCMunich

Indexed as

Immune Checkpoint InhibitorsNeoplasmsAdultAgedAged, 80 and overAmbulatory Care FacilitiesFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeImmune Checkpoint InhibitorsAdverse eventsAutoimmune disordersImmune checkpoint inhibitorsImmunotherapyResponse predictorsSolid tumors

Identifiers

PMID41361351
PMCPMC12686437

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.