Evidence map›Paper›PMID 41361318›Full record

ArticleBMC psychology2025

Association analysis between CD45 lymphocyte counts and the risk of major depressive disorder: a cross-sectional study.

Jiaxin Tian, Jiaxin Feng, Guoping Li, Yanqing Xue, Yanbin Hou, Danjuan Wu, Sheng Nie, Yunxin Ji, Liemin Ruan, Zhongze Lou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiaxin Tian *Department of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University, Zhejiang Regional Medical Center, Ningbo, Zhejiang, 315010, China.
Jiaxin Feng *School of Medicine, Ningbo University, Ningbo, Zhejiang, 315211, China.
Guoping LiResearch Department, Affiliated UB biotechnology (Zhejiang) Co., LTD, Hangzhou, Zhejiang, 315034, China.
Yanqing XueDepartment of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University, Zhejiang Regional Medical Center, Ningbo, Zhejiang, 315010, China.
Yanbin HouDepartment of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University, Zhejiang Regional Medical Center, Ningbo, Zhejiang, 315010, China.
Danjuan WuDepartment of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University, Zhejiang Regional Medical Center, Ningbo, Zhejiang, 315010, China.
Sheng NieDepartment of Neurosurgery, The First Affiliated Hospital of Ningbo University, Zhejiang Regional Medical Center, Ningbo, Zhejiang, 315010, China.
Yunxin JiDepartment of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University, Zhejiang Regional Medical Center, Ningbo, Zhejiang, 315010, China. janegege123@163.com.
Liemin RuanDepartment of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University, Zhejiang Regional Medical Center, Ningbo, Zhejiang, 315010, China. 13805869162@163.com.
Zhongze LouDepartment of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University, Zhejiang Regional Medical Center, Ningbo, Zhejiang, 315010, China. lorenzo_87@163.com.

Funding

Medical and Health Science and Technology Plan Project of Zhejiang Province 2023KY1062Medical and Health Science and Technology Plan Project of Zhejiang Province 2023RC258Ningbo Key Research and Development Program 2022Z145Ningbo Key Research and Development Program 2023Z197Ningbo Natural Science Foundation 2022J207Ningbo Top Medical and Health Research Program 2024010317"Pioneer" and "Leading Goose" R&D Program of Zhejiang 2025C02110"Pioneer" and "Leading Goose" R&D Program of Zhejiang 2025C02250(SD2)
6 · The paper itself

Abstract

The onset and progression of major depression have been closely linked to the human inflammatory immune system, with T cells playing a crucial role in immune function. Recent studies have highlighted significant associations between changes in T cell-related subpopulations and the onset and progression of major depression. So, the aim of this study was to investigate the relationship between T lymphocyte subset alterations and major depressive disorder (MDD). First, a total of 108 participants were included in this study and were categorized according to the International Classification of Diseases Tenth Revision diagnostic criteria (ICD-10) into four groups: the healthy group (n = 30), the mild depression group (n = 26), the moderate depression group (n = 31), and the major depression group (n = 21). Venous blood samples were collected from all participants, and T cell-related subpopulation markers were analyzed through flow cytometry. Statistical analysis revealed a close link between the CD45

Indexed as

Leukocyte Common AntigensMajor Depressive DisorderAdultCross-Sectional StudiesFemaleHumansLymphocyte CountMaleMiddle AgedYoung AdultLeukocyte Common AntigensPTPRC protein, humanCD45+ t lymphocyte countsImmune responseInflammationThe major depression

Identifiers

PMID41361318
PMCPMC12683829

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.