ArticleBMC geriatrics2025
CRP/Albumin ratio combined with age and hand grip strength discriminates malnutrition risk in sarcopenic older adults.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The correlation of CRP/Alb ratio with low muscle mass in patients with type 2 diabetes mellitus: a cross-sectional research.BMC endocrine disorders · 2026Article
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5 authors.
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Abstract
objectiveThis study aimed to evaluate the effectiveness of the C-reactive protein/albumin (CRP/Alb) ratio, in combination with functional indicators such as age and handgrip strength, in identifying malnutrition risk among sarcopenic older adults.
methodsData from individuals aged 65 years and older who were diagnosed with sarcopenia based on the EWGSOP2 (2019) criteria and admitted to a geriatric clinic between 2019 and 2023 were retrospectively analyzed. Nutritional status was assessed using the Mini Nutritional Assessment-Short Form (MNA-SF), with scores of ≤ 7 indicating malnutrition, 8-11 indicating risk of malnutrition, and 12-14 indicating normal nutritional status. Associations between MNA-SF scores and the CRP/Alb ratio, handgrip strength, and age were examined. Binary logistic regression and receiver operating characteristic (ROC) analyses were used to assess the discriminatory power of these variables.
resultsThe study included 168 sarcopenic patients (mean age 78.6 ± 6.7 years; 84.5% female). According to the MNA-SF results, 8.9% of the patients were malnourished, and 45.8% were at risk. CRP/Alb ratio differed significantly across nutritional categories, with higher values in the malnutrition group (median 2.87 [IQR 7.15]) and at-risk group (1.63 [3.98]) compared with the normal nutritional status group (0.83 [1.88]) (p = 0.014). The combined model (CRP/Alb ratio, age, and handgrip strength) had an AUC of 0.807, with a sensitivity of 77.2% and specificity of 68.4%.
conclusionThe CRP/Alb ratio, when combined with age and handgrip strength, may serve as a practical, accessible tool for identifying malnutrition risk in sarcopenic older adults.
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