Evidence map›Paper›PMID 41361247›Full record

ArticleScientific reports2025

A biocompatible propolis pollen and ZnO nanorod composite with antimicrobial and antibiofilm activity.

Mahsa Hakimpour Abyaneh, Laura Pompa, Erica Sonaglia, Mohammad Sharbaf, Gianluca Straface, Flavia Iaculli, Alessandro Giuseppe D'Aloia, Alexia Perrone, Gianni Di Giorgio, Patrizia Mancini and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Understanding the Effect of Propolis and Its Derivatives AgainstJournal of fungi (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mahsa Hakimpour Abyaneh *Dept. of Astronautical, Electrical and Energy Engineering, Sapienza University of Rome, via Eudossiana 18, Rome, 00184, Italy.
Laura Pompa *Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy.
Erica SonagliaDepartment of Chemical Engineering Materials and Environment, Sapienza University of Rome, Via Eudossiana 18, Rome, 00184, Italy.
Mohammad SharbafDepartment of Chemical Engineering Materials and Environment, Sapienza University of Rome, Via Eudossiana 18, Rome, 00184, Italy.
Gianluca StrafaceDepartment of Experimental Medicine, University of Rome, Rome, Italy.
Flavia IaculliDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.
Alessandro Giuseppe D'AloiaDept. of Astronautical, Electrical and Energy Engineering, Sapienza University of Rome, via Eudossiana 18, Rome, 00184, Italy.
Alexia PerroneDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.
Gianni Di GiorgioDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.
Patrizia ManciniDepartment of Experimental Medicine, University of Rome, Rome, Italy.
Maurizio BossùDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy. maurizio.bossu@uniroma1.it.
Antonella PolimeniDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, Rome, 00161, Italy.
Hossein Cheraghi BidsorkhiDept. of Astronautical, Electrical and Energy Engineering, Sapienza University of Rome, via Eudossiana 18, Rome, 00184, Italy. hcheraghi@uniss.it.
Daniela UccellettiDepartment of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy.
Maria Laura SantarelliDepartment of Chemical Engineering Materials and Environment, Sapienza University of Rome, Via Eudossiana 18, Rome, 00184, Italy.
Maria Sabrina SartoDept. of Astronautical, Electrical and Energy Engineering, Sapienza University of Rome, via Eudossiana 18, Rome, 00184, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the context of growing infections, plant-derived natural compounds play a crucial role in the search for new antimicrobial agents, as they offer a diverse array of bioactive molecules. Similarly, nanomaterials, particularly those based on zinc oxide, hold great potential for biomedical applications due to their unique properties. This study evaluates the antimicrobial efficacy of a formulation combining propolis, pollen, and ZnO nanorods (PrPoZnO). SEM and FTIR analysis confirmed ZnO nanorod integration within the propolis-pollen matrix. Antimicrobial testing revealed significant inhibitory effects on Staphylococcus aureus and Pseudomonas aeruginosa, with viability reduction of up to 85% and biofilm inhibition of 50% and 40%, respectively. The PrPoZnO mixture also reduced Candida albicans growth by 90%, inhibited biofilm formation by 60%, and suppressed the yeast-to-hyphae transition, a key virulence factor. Furthermore, the biocompatibility testing of the PrPoZnO mixture in several cell lines demonstrated no cytotoxic effects at the higher concentration, suggesting its potential for safe biomedical applications. In terms of mechanism, PrPoZnO modulated oxidative stress responses, decreasing ROS levels in bacteria while inducing ROS production in C. albicans, suggesting that ZnO nanorods are the key player to induce mechanical damage of microbes. These findings underscore the potential of PrPoZnO as an innovative and biocompatible compound, supporting its suitability for further clinical investigation.

Indexed as

Anti-Infective AgentsBiocompatible MaterialsBiofilmsNanotubesPollenPropolisZinc OxideCandida albicansHumansMicrobial Sensitivity TestsPseudomonas aeruginosaReactive Oxygen SpeciesStaphylococcus aureusAnti-Infective AgentsBiocompatible MaterialsPropolisReactive Oxygen SpeciesZinc OxideCandida albicansNatural substancesPseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID41361247
PMCPMC12689707

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.