Evidence map›Paper›PMID 41361203›Full record

ArticleScientific reports2025

Sulfide silver autometallography to differentiate the ultrastructural localization of iron-carbohydrate complexes inside macrophages.

Anne-Marinette Cao, Jules Duruz, Mauro Sousa de Almeida, Dimitri Vanhecke, Amy E Alston, Reinaldo Digigow, Beat Flühmann, Alke Petri-Fink, Barbara Rothen-Rutishauser

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anne-Marinette CaoAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.
Jules DuruzAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.
Mauro Sousa de AlmeidaAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.
Dimitri VanheckeAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.
Amy E AlstonCSL Vifor, Glattbrugg, Switzerland.
Reinaldo DigigowCSL Vifor, Glattbrugg, Switzerland.
Beat FlühmannCSL Vifor, Glattbrugg, Switzerland.
Alke Petri-FinkAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland. alke.fink@unifr.ch.
Barbara Rothen-RutishauserAdolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland. barbara.rothen@unifr.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron is an essential element for numerous physiological processes in the human body, and maintaining proper iron homeostasis is critical for health. Iron imbalance can lead to conditions like iron deficiency anemia (IDA). Intravenous (IV) iron drugs, including iron-carbohydrate complexes such as iron sucrose (IS) and ferric carboxymaltose (FCM), are commonly used in the treatment of IDA. However, the cellular mechanisms underlying the uptake and intracellular fate of these complexes remain poorly understood despite over seven decades of clinical use. This study introduces a novel application of sulfide silver autometallography (ssAMG) to track iron inside macrophages treated with two widely used intravenous iron products, IS and FCM. Using this technique, the ultrastructural localization of iron in macrophages was visualized in comparison to ferric ion (Fe

Indexed as

Ferric CompoundsIronMacrophagesMaltoseSilverAnemia, Iron-DeficiencyAnimalsFerric Oxide, SaccharatedHumansMiceferric carboxymaltoseFerric CompoundsFerric Oxide, SaccharatedIronMaltoseSilverBiodistributionDrug deliveryElectron microscopyFerric carboxymaltoseIron sucroseSulfide silver autometallography

Identifiers

PMID41361203
PMCPMC12686396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.