ArticleAesthetic plastic surgery2026
A Novel Three-Step Collagen-Augmented Periorbital Comprehensive Treatment: Raise, Enhancement, and Depigmentation.
Article in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A Real-World Study of Polynucleotides HPT for Treating Periorbital Hyperpigmentation.Clinical, cosmetic and investigational dermatology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe periorbital area is one of the first to show signs of aging, including pigmentation, wrinkles, puffiness, and fine lines, affecting both appearance and skin health. This study presents a novel three-step collagen-augmented treatment for periorbital rejuvenation.
methodsSixty-five Chinese Han female patients and three Chinese Han male patients (25-55 years old) with periorbital pigmentation, tear trough deformity, or fine lines were treated with a three-step collagen injection method: raise (lifting and firming periorbital and midface skin), enhancement (reducing tear trough hollowness and smoothing transitions between the lower eyelid and cheek), and depigmentation (reducing pigmentation for improved skin tone). Two independent physicians assessed periorbital aging at baseline, 3, and 6 months post-treatment using Barton grade and Tear Trough Rating Scale (TTRS). Primary outcomes (pigmentation and capillary density changes) were analyzed via 3D reconstruction. Patient satisfaction was measured by FACE-Q scores, and adverse events were recorded.
resultsAll patients achieved satisfactory esthetic outcomes with no significant adverse events. Minor side effects, such as bruising, were observed. At 3 and 6 months post-treatment, significant improvements were noted in dark circles, tear troughs, and fine lines. Pigmentation indices significantly decreased from baseline values of 22.88 ± 5.04-19.08 ± 4.75 at 3 months and to 19.20 ± 4.64 at 6 months (P < 0.025). Capillary density also decreased, indicating thickening of the skin barrier and improved skin health. FACE-Q scores reflected high levels of patient satisfaction.
conclusionsThis novel collagen treatment effectively improved periorbital aging with high patient satisfaction and safety. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.