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ArticleIndian journal of pediatrics2025

Sociodemographic and Clinical Characteristics of Rotavirus Diarrhea in Children Aged Under 5 Years in Odisha After the Introduction of Rotavirus Vaccine: A Hospital-Based Surveillance Study.

Prasantajyoti Mohanty, Pravakar Mishra, Subal Kumar Pradhan, Rajib Kumar Ray, Lipsa Roul, Varsha Sudhir Chaudhary, Anupama Machathi, Namrata Kharat, Tintu Varghese, Ayyappan Vellathur Ramasamy

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Article in Indian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Prasantajyoti MohantyIndian Council of Medical Research (ICMR) Regional Medical Research Centre, Bhubaneshwar, Odisha, India.ORCID 0000-0002-0422-5261
Pravakar MishraDepartment of Pediatrics, Sardar Vallabhbhai Patel Post Graduate Institute of Paediatrics (SVPPGIP) and Srirama Chandra Bhanja (SCB) Medical College, Cuttack, Odisha, India.ORCID 0000-0002-5546-5425
Subal Kumar PradhanDepartment of Pediatrics, Sardar Vallabhbhai Patel Post Graduate Institute of Paediatrics (SVPPGIP) and Srirama Chandra Bhanja (SCB) Medical College, Cuttack, Odisha, India.ORCID 0000-0001-8570-1348
Rajib Kumar RayDepartment of Pediatrics, Sparsh Hospital, Bhubaneswar, Odisha, India. drrajib2007@gmail.com.ORCID 0000-0002-9595-643X
Lipsa RoulDepartment of Pediatrics, Sardar Vallabhbhai Patel Post Graduate Institute of Paediatrics (SVPPGIP) and Srirama Chandra Bhanja (SCB) Medical College, Cuttack, Odisha, India.ORCID 0009-0002-2342-4423
Varsha Sudhir ChaudharyDepartment of Community Medicine, Christian Medical College, Vellore, Tamil Nadu, India.ORCID 0009-0007-3657-040X
Anupama MachathiDepartment of Community Medicine, Christian Medical College, Vellore, Tamil Nadu, India.ORCID 0009-0008-2053-4209
Namrata KharatDepartment of Community Medicine, Christian Medical College, Vellore, Tamil Nadu, India.ORCID 0009-0001-9347-9836
Tintu VargheseThe Wellcome Trust Research Laboratory, Christian Medical College, Vellore, Tamil Nadu, India.ORCID 0000-0001-5246-5043
Ayyappan Vellathur RamasamyDepartment of Community Medicine, Christian Medical College, Vellore, Tamil Nadu, India.ORCID 0009-0002-1660-3204

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesRotavirus diarrhea is a leading cause of death in children aged under 5 y. Odisha introduced Rotavac in April 2016 and switched to ROTASIIL in January 2022. This study aimed to investigate the sociodemographic and clinical characteristics of rotavirus-associated diarrhea in children aged under 5 y in Odisha after the transition to ROTASIIL.

methodsChildren aged under 5 y hospitalized with acute gastroenteritis (AGE) in four hospitals in Odisha between January and December 2023 were enrolled in this cross-sectional study. Stool samples were tested for rotavirus using an enzyme immunoassay. Clinical and demographic data were collected and analyzed according to rotavirus status.

resultsOf 365 children enrolled, 288 had their stool samples tested for rotavirus. Rotavirus was detected in 67 (23.3%) of the samples tested. The incidence of rotavirus-positive AGE was higher in boys than in girls, and rotavirus positivity was higher from November to March than during the rest of the year. Most rotavirus-positive children were of low socioeconomic status. The incidence of severe to very severe dehydration was 78% in the rotavirus-positive group compared with 69.2% in the rotavirus-negative group. No deaths were reported.

conclusionsRotavirus remains an important cause of AGE in children aged under 5 y in Odisha, despite the introduction of rotavirus vaccination. The rotavirus positivity rate was lower than that reported in previous studies, suggesting a positive effect of vaccination. High vaccination coverage, addressing poverty, and prompt clinical management are essential to mitigate the impact of rotavirus diarrhea in Odisha.

Indexed as

DiarrheaGastroenteritisRotavirus InfectionsRotavirus VaccinesChild, PreschoolCross-Sectional StudiesFecesFemaleHospitalizationHumansIncidenceIndiaInfantMaleRotavirusRotavirus VaccinesDehydrationGastroenteritisRotavirusUniversal immunization programVesikari clinical severity score

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