ReviewNPP - digital psychiatry and neuroscience2024
Aligning digital biomarker definitions in psychiatry with the National Institute of Mental Health Research Domain Criteria framework.
Review in NPP - digital psychiatry and neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Personalized Medicine in Psychiatry: From Promise to Practice.Journal of personalized medicine · 2026Article
- AI-enabled passive digital phenotyping of experiential negative symptoms in schizophrenia-spectrum disorders: a narrative review on the path from sensing to clinical endpoints.Frontiers in psychiatry · 2026Review
- Toward terminological clarity in digital biomarker research.Frontiers in digital health · 2026Article
- Exploring the clinical utility of rhythmic digital markers for schizophrenia.PLOS digital health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The field of biological psychiatry faces a growing influx of digital biomarkers spanning self-report, social, behavioral, cognitive, and physiological indicators of various mental health conditions. However, the definition of "digital biomarker," particularly the "bio-" component, remains unclear. This article reviews the terminology of digital biomarkers in psychiatry and argues for the reservation of the term exclusively for measures of biological parameters with a plausible pathway connecting to the disease or condition of interest to enhance terminological clarity and consistency with conventional definitions of biomarker, short for biological marker. While the distinction between biological and non-biological parameters may blur at the edges, the Research Domain Criteria (RDoC) developed by the US National Institute of Mental Health offers a valuable heuristic. The RDoC distinguishes between biological (genes, molecules, cells, neural circuits, physiology) and non-biological (broadly understood behavior and self-report) units of analysis. Aligning digital biomarker definitions in psychiatry with the RDoC framework would mark a significant shift from the current broad usage, where almost any digitally measured characteristic, when used as an indicator, qualifies as a digital biomarker.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.