Evidence map›Paper›PMID 41361028›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Association between intermittent hypoxemia and COVID-19 related isolation and pulmonary outcomes through 2 years of age in infants born preterm.

Juliann M Di Fiore, Zhengyi Chen, Nori Minich, Deanne Wilson-Costello, Richard J Martin, Anna Maria Hibbs

Erratum issuedAbstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Juliann M Di FioreDivision of Neonatology, UH Rainbow Babies & Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. jmd3@case.edu.
Zhengyi ChenDepartment of Population and Quantitative Health Sciences, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-2745-4454
Nori MinichDivision of Neonatology, UH Rainbow Babies & Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Deanne Wilson-CostelloDivision of Neonatology, UH Rainbow Babies & Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.ORCID http://orcid.org/0000-0003-3709-2706
Richard J MartinDivision of Neonatology, UH Rainbow Babies & Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Anna Maria HibbsDivision of Neonatology, UH Rainbow Babies & Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Funding

Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
Prematurity-Related Ventilatory Control: Leadership Data and Coordination Center (LDCC)U01HL133708 · NHLBI · UNIVERSITY OF VIRGINIA · PI LAKE, DOUGLAS E, MOORMAN, JOSEPH RANDALL · 2016 to 2020
$3.7M
Hibbs -Association Between Intermittent Hypoxia and Later Respiratory MorbidityU01HL133643 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI HIBBS, ANNA MARIA, MARTIN, RICHARD JOHN · 2016 to 2020
$2.7M
Patient-Oriented Research and Mentoring Program in Prematurity-Associated Pulmonary MorbidityK24HL143291 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI HIBBS, ANNA MARIA · 2018 to 2022
$598k
NCATS NIH HHS UM1 TR004528NHLBI NIH HHS K24 HL143291NHLBI NIH HHS U01 HL133643NHLBI NIH HHS U01 HL133708U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UM1TR004528U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) K24HL143291U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) U01HL133643U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) U01HL133708
6 · The paper itself

Abstract

backgroundIntermittent hypoxemia events (IH) in preterm infants may alter airway function manifesting as childhood wheezing.

objectiveCharacterize the relationship between IH (first month of life) and wheezing through 12/24 months corrected age. STUDY

designIH < 80% and <90% and number of wheezing episodes were documented in infants <31 weeks gestation discharged prior to and during COVID-19 social isolation.

resultsA greater % time with hypoxemia was associated with increased rates of wheezing through 12 months in infants discharged during COVID-19, (IRRs ranging from 1.07 to 1.32, IH < 80 and 90%, all p < 0.05) and through 24 months in infants <28wks GA discharged during COVID-19 isolation (IRRs, 1.03-1.25, IH < 80 and 90%, all p < 0.05).

conclusionAssociations were seen between IH and wheezing at 12 and 24 months of age predominantly in infants discharged during COVID-19 isolation. No associations were seen through 12 months corrected age in infants discharged during the Pre COVID-19 epoch.

Indexed as

COVID-19HypoxiaInfant, Premature, DiseasesRespiratory SoundsSocial IsolationChild, PreschoolFemaleGestational AgeHumansInfantInfant, NewbornInfant, PrematureMaleSARS-CoV-2

Identifiers

PMID41361028
PMCPMC12981355

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.