Evidence map›Paper›PMID 41360931›Full record

ArticleScientific reports2025

CXCL12 and CXCL13 as potential biomarkers for disease severity and recurrence in respiratory syncytial virus bronchiolitis.

Lin Zhang, Yuanyu Lv, Zhiao Du, Jiawei Chen, Peng Mo, Xuena Xu, Huiming Sun, Yongdong Yan, Canhong Zhu, Li Huang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Lin ZhangDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China.
Yuanyu LvDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China.
Zhiao DuDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China.
Jiawei ChenDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China.
Peng MoDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China.
Xuena XuDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China.
Huiming SunDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China.
Yongdong YanDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China.
Canhong ZhuDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China.
Li HuangDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China.
Chuangli HaoDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China.
Xiuxia ZhouInstitute of Pediatric Clinical Research, Children's Hospital of Soochow University, Suzhou, 215003, China. xiuxia_zhou@126.com.
Heting DongDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China. Heting_0816@163.com.
Zhengrong ChenDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, 215003, China. chen_zheng_rong@163.com.

Funding

Suzhou Science and Education - Driven Healthcare Strengthening Project ZDXM2024008the National Natural Science Foundation of China 82270018the National Natural Science Foundation of China 82271804the National Natural Science Foundation of China 82370020
6 · The paper itself

Abstract

To examine chemokine expression in children with Respiratory Syncytial Virus (RSV) bronchiolitis and evaluate its clinical utility for early warning and prognosis. Five hospitalised RSV bronchiolitis children and five matched controls were studied. To validate findings, 50 RSV infants and 30 controls were assessed for recurrent wheezing after 1 year. Blood leukocyte RNA-seq identified RSV-associated hub genes via GO/KEGG analysis, with flow cytometry confirming chemokine expression. Twelve hub genes were identified, with 712 differentially expressed genes (292 upregulated, 420 downregulated). RSV patients showed elevated CXCL2, CXCL12, CXCL13, CCL13, and CCL24 (P < 0.05). CXCL12 was higher in moderate-to-severe cases (Area Under the Curve, AUC = 0.835, 95% CI 0.714-0.956, P < 0.05), while CXCL13 was elevated in recurrent wheezers (AUC = 0.851, 95% CI 0.711-0.991, P < 0.05). CXCL12 predicted severity, and CXCL13 predicted recurrence (ROC-confirmed, P < 0.05). CXCL12 and CXCL13 may serve as biomarkers for assessing RSV bronchiolitis severity and predicting recurrence, aiding early clinical evaluation and prognosis.

Indexed as

BronchiolitisBronchiolitis, ViralChemokine CXCL12Chemokine CXCL13Respiratory Syncytial Virus InfectionsBiomarkersCase-Control StudiesFemaleHumansInfantMalePrognosisRecurrenceRespiratory Syncytial Virus, HumanSeverity of Illness IndexBiomarkersChemokine CXCL12Chemokine CXCL13CXCL12 protein, humanCXCL13 protein, humanBronchiolitisChemokinesCXCL12CXCL13Respiratory syncytial virus

Identifiers

PMID41360931
PMCPMC12796401

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