Evidence map›Paper›PMID 41360919›Full record

ArticleScientific reports2025

Noninvasive assessment of oxidative stress in pelvic organ prolapse: a feasibility study.

Dominik Habes, Martin Stepan, Ondrej Dvorak, Jana Marie Havigerova, Jiri Haviger, Munachiso Iheme Ndukwe, Tereza Svadlakova, Jan Kestranek, Jiri Spacek, Iva Sedlakova

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Dominik HabesDepartment of Obstetrics and Gynecology, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Králové, Czech Republic.
Martin StepanDepartment of Obstetrics and Gynecology, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Králové, Czech Republic.
Ondrej DvorakDepartment of Obstetrics and Gynecology, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Králové, Czech Republic.
Jana Marie HavigerovaDepartment of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03, Hradec Králové, Czech Republic.
Jiri HavigerDepartment of Informatics and Quantitative Methods, Faculty of Informatics and Management, University of Hradec Králové, Hradecka 1249/6, 500 03, Hradec Králové, Czech Republic.
Munachiso Iheme NdukweDepartment of Obstetrics and Gynecology, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Králové, Czech Republic. munachiso.ndukwe@fnhk.cz.
Tereza SvadlakovaDepartment of Clinical Immunology and Alergology, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
Jan KestranekDepartment of Obstetrics and Gynecology, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Králové, Czech Republic.
Jiri SpacekDepartment of Obstetrics and Gynecology, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Králové, Czech Republic.
Iva SedlakovaDepartment of Obstetrics and Gynecology, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Králové, Czech Republic.

Funding

Cooperatio programe (Charles University) Research Area Maternal and Childhood Care (MATC)
6 · The paper itself

Abstract

Pelvic organ prolapse (POP) is increasingly relevant in aging populations. Oxidative stress (OS) may weaken pelvic support structures, but previous studies relied on invasive tissue sampling, limiting longitudinal use. This study evaluated whether OS markers can be detected non-invasively in vaginal fluid and whether they correlate with POP severity. We prospectively enrolled 160 women with POP between February 2021 and June 2023. Vaginal fluid samples were collected, and three OS markers: 8-hydroxy-2'-deoxyguanosine (8-OHdG), 4-hydroxynonenal (HNE), and advanced glycation end products (AGE) were quantified using commercial ELISA kits. POP severity was assessed by POP-Q and ultrasound parameters. 8-OHdG was consistently detectable and significantly elevated in advanced POP compared to early stages (p = 0.001), showing a modest positive correlation with prolapse severity (ρ = 0.24, p < 0.001). Regression analysis confirmed 8-OHdG as an independent predictor of prolapse severity (R

Indexed as

Oxidative StressPelvic Organ Prolapse8-Hydroxy-2'-DeoxyguanosineAdultAgedAldehydesBiomarkersFeasibility StudiesFemaleGlycation End Products, AdvancedHumansMiddle AgedProspective StudiesSeverity of Illness IndexVagina4-hydroxy-2-nonenal8-Hydroxy-2'-DeoxyguanosineAldehydesBiomarkersGlycation End Products, AdvancedOxidative stressOxidative stress markersPelvic organ prolapseVaginal fluid

Identifiers

PMID41360919
PMCPMC12796472

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.