Evidence map›Paper›PMID 41360911›Full record

ArticleScientific reports2025

Development and evaluation of a mechanical chest compression device for standardized rodent cardiopulmonary resuscitation.

Sam Joé Brixius, Jakob Wollborn, Johannes Dinkelaker, Sonja Bröer, Rita Sanchez-Brandelik, Katharina Denzer, Martin Czerny, Georg Trummer, Felix Particius Hans, Hans-Jörg Busch and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sam Joé BrixiusDepartment of Cardiovascular Surgery, Medical Center, Medical Faculty, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany. sam.brixius@uniklinik-freiburg.de.
Jakob WollbornDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Johannes DinkelakerCenter for Experimental Models and Transgenic Service, Medical Center, Medical Faculty, University of Freiburg, University of Freiburg, Stefan-Meier- Strasse 17, 79104, Freiburg, Germany.
Sonja BröerInstitute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
Rita Sanchez-BrandelikFaculty of Medicine, University of Freiburg, 79085, Freiburg, Germany.
Katharina DenzerDepartment of Cardiovascular Surgery, Medical Center, Medical Faculty, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Martin CzernyDepartment of Cardiovascular Surgery, Medical Center, Medical Faculty, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Georg TrummerDepartment of Cardiovascular Surgery, Medical Center, Medical Faculty, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Felix Particius HansUniversity Emergency Department, Medical Center, Medical Faculty, University of Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Hans-Jörg BuschUniversity Emergency Department, Medical Center, Medical Faculty, University of Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Jan-Steffen PoothUniversity Emergency Department, Medical Center, Medical Faculty, University of Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small animal models are indispensable in cardiopulmonary resuscitation (CPR) research. High-quality CPR, characterized by consistent chest compression rate, depth, and positioning is crucial for survival. However, achieving standardization in manual high-frequency chest compressions in small animal models remains technically challenging. This study evaluated the reproducibility of manual chest compressions and introduced a novel mechanical chest compression device (MCD) designed to improve consistency in rodent experiments. In an in vitro setup, manual compressions were performed by ten participants at target rates ranging from 100 to 260 bpm, guided by a metronome. Compressions performed on a fluid-filled polymer reservoir were analyzed for the compression rate, variability, and time within a ± 10% target range. A color indicator was used to assess the variability of the compression point. A small animal MCD was designed and tested under the same conditions. In vivo, 5 Sprague-Dawley rats underwent 5 min of electrically induced normothermic cardiac arrest followed by 8 min of external chest compressions using the MCD. Obtained data was compared to the in vitro results. A total of 21,650 manual and 20,098 mechanical compressions were analyzed. At 200 bpm, chest compressions using the MCD were significantly more precise (201 ± 1.2 bpm) than manual compressions (218 ± 21 bpm, p < 0.001) with a significant reduced compression point variability (1.7 ± 0.1 cm

Indexed as

Cardiopulmonary ResuscitationHeart ArrestHeart MassageAnimalsDisease Models, AnimalEquipment DesignMaleRatsRats, Sprague-DawleyReproducibility of ResultsArrythmiaCardiopulmonary resuscitationChest compressionEmergency care medicineMechanical chest compression deviceRatsReperfusionRodent animal modelVentricular fibrillation

Identifiers

PMID41360911
PMCPMC12689703

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.