Evidence map›Paper›PMID 41360826›Full record

ArticleScientific reports2025

Uncovering the prognostic implications and immunological roles of transmembrane protein 208 in bladder cancer by multi omics analysis and experimental verification.

Qiancheng Mao, Hongquan Liu, Shangjing Liu, Wenyu Wang, Yini Wang, Keyuan Lou, Yuchen Qian, Jian Ma, Yuanshan Cui, Jitao Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Qiancheng Mao *Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, NO. 20 East Yuhuangding Road, Yantai, 264000, Shandong, China.
Hongquan Liu *Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, NO. 20 East Yuhuangding Road, Yantai, 264000, Shandong, China.
Shangjing LiuDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, NO. 20 East Yuhuangding Road, Yantai, 264000, Shandong, China.
Wenyu WangDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, NO. 20 East Yuhuangding Road, Yantai, 264000, Shandong, China.
Yini WangDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, NO. 20 East Yuhuangding Road, Yantai, 264000, Shandong, China.
Keyuan LouDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, NO. 20 East Yuhuangding Road, Yantai, 264000, Shandong, China.
Yuchen QianDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, NO. 20 East Yuhuangding Road, Yantai, 264000, Shandong, China.
Jian MaDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, NO. 20 East Yuhuangding Road, Yantai, 264000, Shandong, China.
Yuanshan CuiDepartment of Urology, Weifang People's Hospital, Weifang, 261000, Shandong, China. doctorcuiyuan@sina.com.
Jitao WuDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, NO. 20 East Yuhuangding Road, Yantai, 264000, Shandong, China. ylwlurology@163.com.

Funding

National Natural Science Foundation of China Nos. 82370690, 82303813, 82073131Natural Science Foundation of Shandong Province Nos. ZR2023MH241, ZR2023QH271Taishan Scholars Program of Shandong Province Nos. tsqn201909199, tsqn202306403Technology Innovation development plan No.2023JCYJ069
6 · The paper itself

Abstract

In this study, we explored the role of transmembrane protein 208 (TMEM208), a transmembrane protein predominantly located in the endoplasmic reticulum, in bladder cancer (BLCA), where its absence is associated with developmental defects and cellular polarity disorders. Utilizing data from the TCGA database and 15 GEO datasets, we correlated TMEM208 expression with clinical features and employed the ComPPI website and Gene Set Enrichment Analysis (GSEA) to dissect its protein interactions and functional roles. Our analysis revealed that TMEM208 is significantly upregulated in BLCA, positively correlating with clinical severity and poor survival. GSEA indicated associations with oxidative phosphorylation, epithelial-mesenchymal transition, and stemness pathways. Immunoinfiltration analysis showed a predominantly positive correlation with immune cells, except for central memory T cells (Tcm) and T helper cells. Spatial transcriptomics and single-cell sequencing demonstrated TMEM208's predominant expression in tumor cells and fibroblasts, aligning with tumor cell counts, and highlighting its crucial function within the tumor microenvironment. Cellular assays confirmed TMEM208's ability to enhance BLCA cell proliferation, migration, and invasion. In conclusion, TMEM208's overexpression in BLCA suggests its potential as an oncogenic factor, a prognostic indicator of poor outcomes, and a potential therapeutic target.

Indexed as

Membrane ProteinsUrinary Bladder NeoplasmsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMultiomicsPrognosisTranscriptomeTumor MicroenvironmentBiomarkers, TumorMembrane ProteinsBiomarkerBladder cancerImmune infiltrationSingle-cell RNA sequencingSpatial transcriptomeTransmembrane protein 208

Identifiers

PMID41360826
PMCPMC12696045

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.