ArticleNature communications2025
Modifiable influencing factors and their joint effects on early- and late-onset coronary heart disease.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Long-Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modifying genetic susceptibility to coronary heart disease through an integrated plant-based diet-lifestyle.The Lancet regional health. Europe · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Over the past decade, the previously declining trend in coronary heart disease burden has reversed, particularly among younger adults. Using an exposure-wide association study with data from 394,579 UK Biobank participants, we examined the relationship between 213 modifiable factors across eight domains and coronary heart disease. Weighted domain scores were calculated to assess the combined effects of these factors and their interactions with genetic risk. We identified 155 modifiable factors associated with coronary heart disease, 31 of which showed evidence of causality. The major contributors are health and medical history (15.75%), including diabetes mellitus; blood assays (13.87%), including cystatin C; lifestyle factors (10.01%), including time spent watching television; and physical measures (8.70%), including systolic blood pressure. We estimate that 40% to 62% of cases could be prevented by modifying these factors, which have a stronger effect on younger populations. These findings underscore the importance of early and comprehensive prevention strategies.
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Registered trials
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