ReviewCell death & disease2025
Neutrophil extracellular traps in cancer: immune modulation, therapy resistance, and the dilemma of targeting.
Review in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Tumor-Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy-Immunotherapy Combination Trials.International journal of cancer · 2026Review
- PAD4-DB: A Curated Structure-Activity Resource Reveals Hub-Organized Activity Cliffs and Scaffold-Dependent SAR Ruggedness in PAD4 Inhibitors.International journal of molecular sciences · 2026Article
- Review
- Epithelial-mesenchymal transition and immunosuppression: Two sides of the same coin.Cellular and molecular life sciences : CMLS · 2026Review
- Hemostasis at the edge between physiology and cancer.Internal and emergency medicine · 2026Review
- Review
- The spatial landscape of the peritumoral interface: ARG1Frontiers in immunology · 2026Article
- The plasmacytoid dendritic cell paradox in cancer: impaired type I interferon responses in a nucleic acid-rich tumor microenvironment.Frontiers in immunology · 2026Review
- Neutrophil Extracellular Traps in Pancreatic Ductal Adenocarcinoma: A Vicious Cycle in the Tumor Microenvironment and Targeted Interventions.International journal of biological sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The release of extracellular DNA is a highly conserved mechanism across species. Extracellular traps released by neutrophils (NETs) represent a strategic defensive tool of the organism against pathogens, through their direct entrapment and killing, but also through the immunoadjuvant ability of their components. In this review, we discuss the involvement of NETs in cancer, from tumour initiation to recurrence, touching also on their role in cancer-associated comorbidities. We also discuss the emerging contribution of NETs in resistance to chemotherapy, radiotherapy and, particularly, immunotherapy, because of their suppression of cytotoxic immune responses and remodelling of the tumour microenvironment into an immune-tolerant niche. The therapeutic dilemma lies in whether targeting NETs to restore anti-tumour immunity may compromise the host's defence against infections, an adverse effect that is far from negligible in patients who are often already immunocompromised. Furthermore, despite their widely recognized pro-tumoral functions, NETs have also been implicated in supporting anti-tumour immunity in specific contexts. The key challenge, therefore, lies in distinguishing between "bad" pro-tumoral NETs and "good" anti-microbial/anti-tumoral NETs, both for identifying reliable biomarkers and for developing more precise NET-based therapeutic targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.