ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Artificial intelligence-guided nanozyme engineering for chronic wound healing: from rational design to precision therapeutics.Bioactive materials · 2027Review
- Stress-Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Multiscale bone remodeling in COVID-19: from osteoimmune signaling to structural and mechanical impairment.Frontiers in bioengineering and biotechnology · 2026Review
- Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Mechanical cues are fundamental regulators of stem cell fate and play critical roles in various biological processes, including embryogenesis, tissue repair, and regeneration. Successfully reconstructing the complex and dynamic mechanical microenvironments of human tissues necessitates innovative biomaterial designs that surpass conventional approaches. This review provides a comprehensive overview of recent advances in the field of biomaterial-mediated mechanomodulation of stem cell fate, encompassing both mechanobiological dynamics and dynamic mechanomodulatory biomaterials. It is also discussed how specific material properties, such as stiffness, nanotopography, shear stress, and dynamic stimuli-responsive behavior, can be used to precisely control stem cell processes, including proliferation, differentiation, migration, and apoptosis. Furthermore, the application of these strategies is examined in both conventional and advanced culture systems, such as organoids and organ-on-chip platforms, with a particular focus on tissue-engineering applications in the neurological, musculoskeletal, and endocrine systems. It is further discussed how material innovations have enabled the development of cutting-edge techniques for investigating mechanotransduction in stem cells, including force probes, non-invasive biosensors, materiomics, and machine learning. By integrating knowledge from diverse fields, including medicine, materials science, engineering, biology, and biophysics, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of mechanotherapies and advance the field of regenerative medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.