Evidence map›Paper›PMID 41360513›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2026

[Construction of a prognosis forecasting model for breast cancer based on lipid metabolism-related genes and functional verification of

Zirong Lu, Yufeng Lu, Ji Zhou, Yichao Zhu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Zirong LuSchool of Pediatrics, Nanjing Medical University, Nanjing 210008, China. luzirong@stu.njmu.edu.cn.
Yufeng LuExperimental Teaching Center of Basic Medicine, Nanjing Medical University, Nanjing 211166, China.
Ji ZhouDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China.
Yichao ZhuDepartment of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China. zhuyichao@njmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the expression patterns and prognostic value of lipid metabolism-related genes in breast cancer.

methodsRNA sequencing data and clinical information were obtained from The Cancer Genome Atlas breast cancer-related gene (TCGA-BRCA) cohort, including 1100 breast cancer tissue samples and 112 normal breast tissue samples. Differentially expressed lipid metabolism-related genes were screened from a predefined set of 2043 genes using Bioconductor in R, with a false discovery rate <0.05 and |log

resultsA total of 185 differentially expressed lipid metabolism-related genes were identified. Univariate Cox and LASSO regression analyses identified three genes-

conclusionsThis study established and validated a prognosis forecasting model for breast cancer based on lipid metabolism-related genes. It revealed that reduced

Indexed as

Aldehyde Dehydrogenase, MitochondrialBreast NeoplasmsLipid MetabolismFemaleHumansNomogramsPrognosisProportional Hazards ModelsAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanAldehyde dehydrogenase 2Breast cancerForecasting modelLipid metabolism-related genesPrognosis

Identifiers

PMID41360513
PMCPMC12972871

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