Evidence map›Paper›PMID 41360505›Full record

ArticleThe European respiratory journal2026

The transcriptome of CD14

Theodoros Karampitsakos, Minxue Jia, Bochra Tourki, Zainab Fatima, Bogdan Visinescu, Carole Y Perrot, Tamer Fadli, Amy Zhao, Avraham Unterman, Marc A Schneider and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Theodoros KarampitsakosDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Minxue JiaDepartment of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-9305-1218
Bochra TourkiDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Zainab FatimaDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Bogdan VisinescuAssociates in Discipline, Columbia Engineering, Artificial Intelligence Program, Columbia University, New York, NY, USA.
Carole Y PerrotDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Tamer FadliDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Amy ZhaoPulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Avraham UntermanPulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-0965-3326
Marc A SchneiderTranslational Research Unit, Thoraxklinik at Heidelberg University Hospital and Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.ORCID https://orcid.org/0000-0001-8269-3821
Debabrata BandyopadhyayDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.ORCID https://orcid.org/0000-0002-5323-9061
Brenda M Juan-GuardelaDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Ioannis VamvakarisDepartment of Pathology, Hospital for Thoracic Diseases, "SOTIRIA", Athens, Greece.
Antje PrasseDepartment of Pulmonology, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0002-7336-7458
Imre NothUniversity of Virginia, Division of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Charlottesville, VA, USA.
Stephen LiggettDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Michael KreuterLung Center Mainz, Department of Pneumology, University Medical Center Mainz and Department of Pulmonary, Critical Care and Sleep Medicine, Marienhaus Clinic Mainz, Mainz, Germany.
Wonder DrakeDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Argyris TzouvelekisPulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Joe G N GarciaUniversity of Florida, The Herbert Wertheim UF Scripps Research Institute, Jupiter, FL, USA.
Erica HerzogPulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Naftali KaminskiPulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-5917-4601
Panayiotis V BenosDepartment of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0003-3172-3132
Jose D Herazo-MayaDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA jherazomaya@usf.edu.ORCID https://orcid.org/0000-0002-8129-6346

Funding

Structure-Function Analysis of nmMLCK in EC Barrier ResponsesP01HL126609 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia · 2016 to 2026
$24.4M
NHLBI NIH HHS P01 HL126609
6 · The paper itself

Abstract

backgroundThe association between immune-cell-specific transcriptomic profiles and mortality in idiopathic pulmonary fibrosis (IPF) is unknown.

methodsWe profiled peripheral blood mononuclear cells by single-cell RNA sequencing (scRNA-seq) and investigated which immune-cell-specific transcriptomic profile predicted IPF outcomes consistently. Prognostic accuracy was investigated in peripheral blood mononuclear cells (PBMCs), bronchoalveolar lavage (BAL) and lung tissue. Findings were validated by flow cytometry, analysis of independent scRNA-seq datasets and cellular deconvolution. We investigated the function of this transcriptomic profile and its cellular source in lung tissue (overall sample size, n=1054; IPF, n=555; other, n=499). Connectivity map analysis and LASSO regression were used to identify drug candidates and a subset of genes with prognostic potential, respectively.

resultsA 230-gene up-score (Pittsburgh PBMC cohort) from CD14

conclusionsThe transcriptome of CD14

Indexed as

HLA-DR AntigensIdiopathic Pulmonary FibrosisMonocytesTranscriptomeAgedAntigens, CDBronchoalveolar Lavage FluidCD163 AntigenFemaleGene Expression ProfilingHumansLeukocytes, MononuclearLipopolysaccharide ReceptorsLungMaleMiddle AgedAntigens, CDCD14 protein, humanCD163 AntigenHLA-DR AntigensLipopolysaccharide ReceptorsReceptors, Cell Surface

Identifiers

PMID41360505
PMCPMC13150356

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.