Evidence map›Paper›PMID 41360480›Full record

Trial reportBMJ global health2025

Integrating point-of-care screening for curable sexually transmitted infections with HIV, syphilis and hepatitis B screening in antenatal care services in Zimbabwe: a mixed-methods process evaluation.

Kevin Martin, Constance R S Mackworth-Young, Ethel Dauya, Rangarirayi Nyamwanza, Chido Dziva Chikwari, Maureen Tshuma, Joseph D Tucker, Victoria Simms, Tsitsi Bandason, Francis Ndowa and 7 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in BMJ global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05541081 (Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Primary Care in Zimbabwe), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05541081 nacompletednot on this map

Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Primary Care in Zimbabwe

TypeinterventionalSponsorLondon School of Hygiene and Tropical MedicineRan2023 to 2024Enrolled1,005ConditionsSexually Transmitted Infection, Chlamydia, Gonorrhea, TrichomoniasisArmsPoint-of-care STI testing
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kevin MartinDepartment of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK kevinmartin@doctors.org.uk.ORCID 0000-0001-6561-1353
Constance R S Mackworth-YoungThe Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe.
Ethel DauyaThe Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe.
Rangarirayi NyamwanzaThe Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe.
Chido Dziva ChikwariThe Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe.ORCID 0000-0003-1617-3603
Maureen TshumaThe Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe.
Joseph D TuckerDepartment of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
Victoria SimmsThe Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe.ORCID 0000-0002-4897-458X
Tsitsi BandasonThe Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe.
Francis NdowaSkin & Genito-Urinary Medicine Clinic, Harare, Harare Province, Zimbabwe.
Leolin KatsidziraInternal Medicine Unit, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Owen MugurungiAIDS and TB Unit, Ministry of Health and Child Care, Harare, Zimbabwe.
Anna MachihaAIDS and TB Unit, Ministry of Health and Child Care, Harare, Zimbabwe.
Remco P H PetersResearch Unit, Foundation for Professional Development, East London, South Africa.
Michael MarksDepartment of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
Katharina KranzerThe Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe.
Rashida A FerrandDepartment of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-7660-9176

Funding

Wellcome TrustWellcome Trust 225468/Z/22/Z
6 · The paper itself

Abstract

introductionSexually transmitted infections (STIs) in pregnancy are associated with adverse birth outcomes. We investigated the uptake and yield of point-of-care screening for

methodsA prospective interventional study was conducted in two public-sector ANC clinics in Harare. Clients attending for ANC were screened in parallel for

resultsBetween 12 January 2023 and 23 October 2023, there were 13 500 ANC attendances over 207 implementation days. Of 1105 (8.2%) assessed for eligibility, 1103 (99.8%) were eligible, of whom uptake of the full screening package was 91.0% (1004/1103). Curable STI prevalence was 30.7% (308/1003), of whom 303 (98.4%) received same-day treatment. HBV prevalence was 1.4% (14/1003). The prevalence of HIV was 10.5% (105/1003), with 20 (19.0%) being new diagnoses.Although the intervention was highly acceptable, diagnostic capacity and workload were barriers to recruitment. In particular, the collection and testing of multiple sample types with different tests, with a range of reading times, was challenging.

conclusionWe demonstrated high levels of acceptability, screening uptake and same-day treatment. However, a low proportion of ANC attendees were enrolled overall, and current technological limitations preclude this particular testing strategy from being scaled up beyond low-volume settings. We recommend investment into the development of STI point-of-care tests with shorter analytic times and research into alternative strategies involving laboratory-based high-throughput testing. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT05541081; registered 15 September 2022.

Indexed as

Mass ScreeningPoint-of-Care TestingPregnancy Complications, InfectiousPrenatal CareSexually Transmitted DiseasesAdultFemaleHepatitis BHIV InfectionsHumansPregnancyProspective StudiesSyphilisYoung AdultZimbabweGlobal HealthHealth services researchMaternal healthScreeningZimbabwe

Identifiers

PMID41360480
PMCPMC12684121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.