Evidence map›Paper›PMID 41360404›Full record

ArticleJournal of gastroenterology and hepatology2026

Psychosine Alleviates Colitis via Inhibiting Th1 and Th17 Cell Immune Responses in Inflammatory Bowel Diseases.

Ritian Lin, Jiayi Tu, Shan Li, Qinjuan Sun, Lan Zhong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ritian LinDepartment of Gastroenterology, Shanghai East Hospital, Tongji University of School Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-3867-0061
Jiayi TuDepartment of Gastroenterology, Shanghai East Hospital, Tongji University of School Medicine, Shanghai, China.
Shan LiDepartment of Gastroenterology, Shanghai East Hospital, Tongji University of School Medicine, Shanghai, China.
Qinjuan SunDepartment of Gastroenterology, Shanghai East Hospital, Tongji University of School Medicine, Shanghai, China.
Lan ZhongDepartment of Gastroenterology, Shanghai East Hospital, Tongji University of School Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-6947-3266

Funding

Investigator-initiated Trial Program of Shanghai Pudong New Area Health Commission (the Cohort Study Program) 2024-PWDL-01National Natural Science Foundation of China 82300604：82270639
6 · The paper itself

Abstract

backgroundAberrant T-helper 1 (Th1) and Th17 cell activation is involved in the pathogenesis of inflammatory bowel disease (IBD). Psychosine is known to induce apoptosis, promote astrocyte activation, and inhibit osteoclastogenesis. However, the role of psychosine on Th1 and Th17 cell immune responses has not been previously reported. In this study, we investigate the role of psychosine in the modulation of CD4

methodsPeripheral blood CD4

resultsWe found that psychosine suppresses the expression of IFN-γ and IL-17A and Th1 and Th17 cell differentiation in PB-CD4

conclusionOur data reveal that psychosine reduces mucosal inflammation by preventing excessive Th1 and Th17 cell-mediated immune responses. Supplementation of psychosine may serve as a novel therapeutic approach for the treatment of IBD.

Indexed as

ColitisInflammatory Bowel DiseasesPsychosineTh17 CellsTh1 CellsAnimalsCell DifferentiationCell ProliferationCells, CulturedDisease Models, AnimalFemaleHumansInterferon-gammaInterleukin-17MaleMiceInterferon-gammaInterleukin-17Psychosineinflammatory bowel diseasepsychosineTh17 cellsTh1 cells

Identifiers

PMID41360404
PMCPMC12887622

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.