Evidence map›Paper›PMID 41360282›Full record

ArticleDevelopmental biology2026

Epicardial Tcf21 facilitates cardiomyocyte dedifferentiation and heart regeneration in zebrafish.

Miglė Kalvaitytė-Repečkė, Sofija Gabrilavičiūtė, Kotryna Kvederavičiūtė, Leonard Burg, Edita Bakūnaitė, Kenneth D Poss, Darius Balciunas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miglė Kalvaitytė-RepečkėInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania. Electronic address: migle.kalvaityte@gmc.vu.lt.
Sofija GabrilavičiūtėInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
Kotryna KvederavičiūtėInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
Leonard BurgDepartment of Biology, Temple University, Philadelphia, USA.
Edita BakūnaitėInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
Kenneth D PossMorgridge Institute for Research, Department of Cell & Regenerative Biology, University of Wisconsin-Madison, Madison, USA.
Darius BalciunasInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania; Department of Biology, Temple University, Philadelphia, USA. Electronic address: darius.balciunas@temple.edu.

Funding

Leveraging zebrafish models to dissect and enhance heart regenerationR35HL150713 · NHLBI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI KENNETH D POSS · 2020 to 2026
$6.9M
NHLBI NIH HHS R35 HL150713
6 · The paper itself

Abstract

Unlike mammals, zebrafish (Danio rerio) are able to regenerate their hearts after injury, making them an excellent model organism for studying the molecular mechanisms underlying heart regeneration. Epicardium, the outermost layer of the heart, is an essential player in this process. Injury-induced epicardium activation, characterized by the expression of embryonic epicardial marker genes including tcf21, supports cardiac regeneration by providing various cell types and releasing paracrine signals that promote the restoration of damaged tissue. However, the molecular mechanisms involved in this process are insufficiently understood. In this study, we describe a conditional tcf21

Indexed as

Basic Helix-Loop-Helix ProteinsCell DedifferentiationHeartMyocytes, CardiacPericardiumRegenerationZebrafishZebrafish ProteinsAnimalsAnimals, Genetically ModifiedTamoxifenBasic Helix-Loop-Helix ProteinsTamoxifenZebrafish ProteinsCardiomyocyte dedifferentiationConditional alleleEpicardiumHeart regenerationTcf21

Identifiers

PMID41360282
PMCPMC13032862

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.