ArticleJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews2025
Primary Diagnoses Associated With and Outcomes of Total Knee Arthroplasty in Patients Aged 15 to 45 Years.
Article in Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Clinical outcomes observed with Rivaroxaban versus low molecular weight heparin (Enoxaparin) for thrombo-prophylaxis following total knee arthroplasty: a meta-analysis.BMC cardiovascular disorders · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundTotal knee arthroplasty (TKA) in younger patients is relatively uncommon.
methodsThe PearlDiver M165Ortho data set was used to identify TKA patients aged 15 to 45 years. Primary diagnoses associated with surgery were categorized into the following groups: primary osteoarthritis (OA), posttraumatic arthritis (PTOA), rheumatoid arthritis (RA), and osteonecrosis. Ninety-day adverse events and readmissions and 10-year periprosthetic fractures, loosening, stiffness, revisions, and prosthetic joint infection (PJI) were determined. Independent predictors of adverse outcomes were identified by using multivariable analysis, and Kaplan-Meier survival analysis for 10-year revisions was performed.
resultsA total of 26,566 TKA patients aged 15 to 45 years were identified. Among this cohort, the diagnosis associated with surgery was OA for 22,900 (86.2%), PTOA for 1648 (6.2%), RA for 1438 (5.4%), and osteonecrosis for 580 (2.2%). For the entire study cohort, 90-day adverse events were noted for 11.1% and readmissions for 7.4%. The 10-year periprosthetic fracture rate was 0.2%, aseptic loosening rate was 3.6%, stiffness rate was 26.9%, revision rate was 7.9%, and PJI rate was 5.7%. Diagnosis associated with surgery was not predictive of 90-day outcomes or 10-year adverse periprosthetic fracture, aseptic loosening, stiffness, or revisions. On Kaplan-Meier analysis, survival was clinically similar across all diagnosis groups, ranging from 86.2% to 89.7% at 10 years.
conclusionYoung TKA patients experience relatively low 90-day adverse events and readmissions and long-term complications regardless of diagnosis associated with surgery. Implant survival is similarly to what is observed in older TKA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.