Evidence map›Paper›PMID 41359849›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Galectin-related protein, a key contributor, drives diabetes-associated neuropathic pain.

Danyang Chen, Jing Wang, Xiang-Jie Song, Zi-Jiao Ding, Qianqian Lou, Yuan-Yuan Chen, Meng-Yuan Wang, Xin-Lu Yang, Zhi Zhang, Juan Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A neuron-astrocyte signaling axis in the ACC sustains diabetic neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Galectin-related protein, a key contributor, drives diabetes-associated neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Danyang Chen *Department of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Jing Wang *Department of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Xiang-Jie Song *Core Facility Centre for Life Science, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Zi-Jiao DingDepartment of Anatomy, Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Qianqian LouDepartment of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Yuan-Yuan ChenDepartment of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Meng-Yuan WangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei 230001, China.
Xin-Lu YangDepartment of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Zhi ZhangDepartment of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0002-4205-3181
Juan LiDepartment of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Wei WangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei 230001, China.ORCID 0000-0002-4123-8280
Haitao WangDepartment of Central Laboratory, College & Hospital of Stomatology, Anhui Provincial Key Laboratory of Oral Diseases Research, Anhui Medical University, Hefei 230022, China.ORCID 0000-0002-2436-113X

Funding

CAS Project for Young Scientists in Basic Research YSBR-013National Key Research and Development Program of China STI2030-Major Projects 2021ZD0203100National Natural Science Foundation of China 32271176National Natural Science Foundation of China 32471182National Natural Science Foundation of China 32530043 32025017National Natural Science Foundation of China 82401441National Natural Science Foundation of China U23A20508Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM QYZD20220007USTC Research Funds of the Double First-Class Initiative YD9100002501USTC Research Funds of the Double First-Class Initiative YD9110002015USTC Research Funds of the Double First-Class Initiative YD9110002065
6 · The paper itself

Abstract

Neuropathic pain associated with central sensitization is common in diabetic patients, but the underlying mechanisms remain unclear. Here, a proteomics screen identified a previously uncharacterized protein, galectin-related protein (LGALSL), which was significantly upregulated in cerebrospinal fluid and extracellular fluid of the anterior cingulate cortex (ACC) in diabetes-related neuropathic pain (DNP) model rats. Exogenous LGALSL administration reduced mechanical nociceptive thresholds by activating glutamatergic neurons in the ACC (ACC

Indexed as

Diabetes Mellitus, ExperimentalDiabetic NeuropathiesGalectinsNeuralgiaAnimalsAstrocytesMaleNeuronsRatsRats, Sprague-DawleyVimentinGalectinsVimentinanterior cingulate cortexdiabetes-associated neuropathic paingalectin-related protein

Identifiers

PMID41359849
PMCPMC12718390

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.