Evidence map›Paper›PMID 41359834›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Multiple weak brakes act in concert to control STIM1 and store-operated calcium entry.

Ruoyi Qiu, Richard S Lewis

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Listening to the quiescence of single STIM1 dimers.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ruoyi QiuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-9484-4375
Richard S LewisDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-6010-7403

Funding

Ion Channels and Signaling Mechanisms in T LymphocytesR37GM045374 · NIGMS · STANFORD UNIVERSITY · PI LEWIS, RICHARD S · 2012 to 2021
$6.2M
Molecular and cellular mechanisms of store-operated calcium channelsR35GM149305 · NIGMS · STANFORD UNIVERSITY · PI LEWIS, RICHARD S · 2023 to 2025
$1.7M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM149305HHS | NIH | National Institute of General Medical Sciences (NIGMS) R37GM45374NIGMS NIH HHS R35 GM149305NIGMS NIH HHS R37 GM045374
6 · The paper itself

Abstract

Store-operated Ca

Indexed as

CalciumCalcium SignalingNeoplasm ProteinsStromal Interaction Molecule 1Endoplasmic ReticulumFluorescence Resonance Energy TransferHEK293 CellsHumansModels, MolecularORAI1 ProteinProtein DomainsCalciumNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1calcium signalingsingle-molecule FRETSTIM1store-operated calcium entry

Identifiers

PMID41359834
PMCPMC12718381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.