ArticlePloS one2025
Lactate dehydrogenase is an indicator for outcomes of short-term and long-term in septic patients.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Prognostic Value of Serial Lactate Dehydrogenase Measurements for Determining Early Mortality in ICU Patients: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Article
- 10-epi-Protectin DX and Resolvin D5International journal of molecular sciences · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe association between lactate dehydrogenase (LDH) and clinical outcomes in sepsis was explored based on MIMIC-IV database.
methodsThis was a retrospective study. Models including unadjusted model and adjusted models were performed for exploring the association of LDH with 30-day mortality and 1-year mortality. The smooth fitting curves were constructed by using generalized additive model. The predictive value of LDH for clinical outcomes in sepsis was evaluated. The statistical software of EmpowerStats (http://www. empowerstats. com) and R (http://www.R-project.org) were applied for analysis.
results6775 sepsis patients were included. After adjusted for all potential confounders, for every 100 IU/L increment in LDH, the risk of 30-day mortality and 1-year mortality increased by 11% (odds ratio (OR)=1.11, 95%CI:1.08-1.13, P < 0.0001) and 12% (OR=1.12, 95%CI:1.09-1.14, P < 0.0001), respectively. The areas under the ROC curve of LDH for predicting mortalities of 30-day and 1-year were 0.667 (95%CI:0.652-0.681) and 0.646 (95%CI: 0.632-0.660), respectively.
conclusionLDH was positively correlated with 30-day and 1-year mortalities in sepsis and the relationship was nonlinear.
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