Trial reportEuropean journal of applied physiology2026
Arterio-venous metabolite and electrolyte responses to low-load training with and without blood flow restriction versus high-load training to failure.
Trial report in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Acute Autonomic and Perceptual Responses to Resistance Training Performed With and Without Blood Flow Restriction.Journal of functional morphology and kinesiology · 2026Article
- Molecular Mechanisms, Physiological Effects, Gut Microbiota Interplay and Nutritional Strategies of Anthocyanins as Modulators of Muscle Protein Synthesis: A Narrative Review.Current nutrition reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLow-load resistance training with blood flow restriction (BFR) has gained popularity for eliciting muscular adaptations comparable to high-load resistance training. However, its acute metabolic and electrolyte responses within the exercising limb, particularly under exhaustive conditions, remain insufficiently characterized. This study aimed to assess these responses using simultaneous arterial and venous blood sampling during unilateral elbow flexion to volitional failure under three conditions: low-load (LL-RT, 30%1RM), low-load with BFR (LL-BFR-RT, 30%1RM, 50%LOP), and high-load (HL-RT, 75%1RM).
methodsTen healthy men (26.8 ± 4.6 years) completed all exercise conditions in a randomized cross-over design. Catheters were placed in the radial artery and antecubital vein of the exercising arm. Serum creatine kinase (CK) and lactate dehydrogenase (LDH) were assessed as indirect muscle damage markers.
resultsLL-RT produced the highest total workload (692 ± 251 kg), exceeding both LL-BFR-RT (378 ± 58.7 kg) and HL-RT (327 ± 65.1 kg, p < 0.001). Muscle pain perception assessed using a visual analog scale increased during exercise, with a highest level in LL-BFR-RT (p < 0.01). LL-BFR-RT also induced the most pronounced venous perturbations (e.g., reduced pH and sO
conclusionThese findings suggest that LL-BFR-RT to failure induces substantial local metabolic and ionic stress within the exercising limb despite reduced mechanical loading. The marked venous disturbances, alongside minimal increases in systemic damage markers, support its use as a metabolically potent yet mechanically efficient training modality when applied with care.
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