Observational studyJournal of neuro-oncology2025
Preoperative nTMS-based mapping of a verbal semantic association task allows for the identification of extensive bihemispheric cortical and subcortical networks.
Observational study in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06401057 (Register for Longitudinal Recording of Brain Function in Patients With Brain Diseases), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Register for Longitudinal Recording of Brain Function in Patients With Brain Diseases
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Authors and funding
5 authors.
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Abstract
purposeAccurately mapping higher cognitive functions remains a challenge both intraoperatively and preoperatively. This study is the first to preoperatively evaluate the bihemispheric cortical and subcortical networks by preoperative nTMS-based mapping of a verbal semantic association task, based on the intraoperatively established Pyramids and Palm Trees Test (PPTT).
methodsThe PPTT was integrated into the established workflow of preoperative nTMS-based mapping. Fibertracking (FT) was performed using a fractional anisotropy (FA) threshold set at 50% of the maximum FA and a minimum fiber length (FL) of 100 mm.
resultsThe study included 20 patients with right-sided gliomas. Overall error rates in the lesional (right) hemisphere were 0.108 ± 0.053, compared to 0.098 ± 0.047 in the contralateral (left) hemisphere (p = 0.215). Semantic errors were observed more frequently in the right hemisphere (right: 0.0275 ± 0.015, left: 0.016 ± 0.015; p = 0.01). Tractography-based network analysis demonstrated comparable network properties regarding fiber volumes (left: 36 ± 16 (14-83) cm
conclusionThe PPTT, when used as a verbal semantic association task, enables a function-based identification of the bihemispheric network underlying semantic association and complex language processing. Function-based FT revealed an extensive right-hemispheric network, comparable in volume, mean FA and fiber length to the left hemisphere. These findings suggest that bihemispheric networks are crucial in higher cognitive functions, including semantic processing during complex language tasks. CLINICAL TRIAL NUMBER: The trial was registered on clinicaltrials.gov (NCT06401057) on January 7th 2024.
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