ArticleGenes & genomics2026
De novo identification and differential expression of MicroRNA in the Lebbeus groenlandicus.
Article in Genes & genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
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Abstract
backgroundCaridean shrimps remain under-studied despite their economic value. Lebbeus groenlandicus (L. groenlandicus) lacks foundational molecular resources, limiting management and aquaculture applications. MicroRNAs (miRNAs) regulate immunity and metabolism and offer biomarker potential, yet no miRNAome has been reported for this species.
objectiveTo generate the first miRNAome for L. groenlandicus, characterize orthologous and novel miRNAs, and assess tissue-specific expression.
methodSmall RNA-seq libraries (15–35 nt) were prepared from the hepatopancreas and muscle of three individuals (six libraries). Reads were aligned to human, mouse, and zebrafish miRNA references; miRDeep2 was used for discovery/quantification, with BLASTN, intersection, and MFE analyses for validation. Differential expression was tested with DESeq2; qRT-PCR evaluated species specificity of candidates.
resultsOn average, 25.17% of reads mapped to known miRNAs, yielding average 117 known miRNAs per tissue and average 25 novel candidates per tissue. Cross-species alignment and intersection defined 61 orthologous miRNAs. Hepatopancreas showed strong up-regulation of several novel miRNAs and orthologs miR-1260a, miR-184, miR-7a-1; down-regulated sets included novel miRNAs and orthologs miR-1a-2, miR-133a-2, miR-10a, miR-5004. miR-10a was evolutionarily conserved. Candidate NM00003 exhibited a stable stem-loop structure and species-specific expression.
conclusionWe deliver the first miRNAome for L. groenlandicus, revealing conserved regulators of immunity and metabolism, and identify novel miRNAs as practical biomarker candidates for aquaculture monitoring and stock management.
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