Evidence map›Paper›PMID 41359234›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2026

A single centre experience of pulsed field ablation for atrial fibrillation using the Medtronic PulseSelect System: an analysis of the first 100 patients.

Zuhayr Minhaj Siddiqui, Charles Yao-Cheng Ho, Khang-Li Looi, Marlynn Ali, Andrew Martin, Nigel Lever, Jamie Voss, Andrew Gavin, Fang Shawn Foo, Matthew O'Connor

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Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zuhayr Minhaj SiddiquiDepartment of Cardiology, Auckland City Hospital, 2 Park Road, Grafton, Auckland, 1023, New Zealand. zuhayr@adhb.govt.nz.ORCID http://orcid.org/0000-0003-1000-6951
Charles Yao-Cheng HoDepartment of Cardiology, Auckland City Hospital, 2 Park Road, Grafton, Auckland, 1023, New Zealand.
Khang-Li LooiDepartment of Cardiology, Auckland City Hospital, 2 Park Road, Grafton, Auckland, 1023, New Zealand.
Marlynn AliDepartment of Cardiology, Auckland City Hospital, 2 Park Road, Grafton, Auckland, 1023, New Zealand.
Andrew MartinDepartment of Cardiology, Auckland City Hospital, 2 Park Road, Grafton, Auckland, 1023, New Zealand.
Nigel LeverAuckland City Hospital, University of Auckland, Auckland, New Zealand.
Jamie VossMiddlemore Hospital, Auckland, New Zealand.
Andrew GavinNorth Shore Hospital, Auckland, New Zealand.
Fang Shawn FooNorth Shore Hospital, Auckland, New Zealand.
Matthew O'ConnorDepartment of Cardiology, Auckland City Hospital, 2 Park Road, Grafton, Auckland, 1023, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulsed Field Ablation (PFA) has been rapidly adopted as a method of Pulmonary Vein Isolation (PVI) for patients with atrial fibrillation (AF). As a non-thermal, tissue-selective technique it may reduce or eliminate some of the complications observed with radiofrequency or cryo-ablation including oesophageal fistula formation and phrenic nerve palsy. It appears to be as efficacious and safer than thermal based ablations. We evaluated the first 100 patients who underwent ablation using the PulseSelect PFA system (Medtronic, Minneapolis, USA) at our centre.

methodsAll patients who underwent AF ablation using the PulseSelect PFA system between May 2024 and February 2025 were identified from our local, prospective registry. Primary outcome was successful intra-procedural PVI. Secondary outcomes included adverse events, procedure duration, fluoroscopy time and same-day discharge.

resultsAll of the patients achieved PVI. Additional non-PV target ablations were performed in 39 patients (22 radiofrequency CTI line ablations, 18 other targets). Five (5%) had procedural complications, two of which related to vascular access. Median procedural time was 85 min for all procedures, and 70 min for PVI-only, with improved times as user experience increased. Median fluoroscopy time was 20 min. Same-day discharge was achieved in 49 patients.

conclusionPFA using Medtronic's PulseSelect System is an effective and safe method of achieving PVI. Our data would suggest it is a quicker procedure than thermal based ablation, which rapidly improved with user experience. The long-term durability of PVI requires further follow-up.

Indexed as

Atrial FibrillationCatheter AblationIrreversible Electroporation TherapyPulmonary VeinsAgedFemaleHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesRegistriesTreatment OutcomeAtrial fibrillationPulmonary vein isolationPulsed field ablationPulse select

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.