ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2026
Red light (630 nm) combined with low-dose ALA-PDT: a novel strategy for collagen remodeling and anti-aging efficacy.
Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research advances in the pathogenesis and photodynamic therapy of pathological scars.Lasers in medical science · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
As an effective minimally invasive therapy for skin aging, 5-aminolevulinic acid photodynamic therapy (ALA-PDT) demonstrates superior efficacy. While Light-emitting diode (LED)-PDT offers advantages of broad-spectrum capabilities and low-cost over conventional laser-PDT, the absence of standardized parameter optimization impedes its clinical application. This study systematically investigated the combined effects of varying ALA concentrations and LED wavelengths to establish an optimized anti-aging protocol. Sixty mice (40 UVB-induced photoaging, 20 natural aging) were randomized into 12 groups receiving PDT with different ALA concentrations (2%/5%/10%), LED wavelengths (405/532/630 nm), and light dose (4.5/18 J/cm²). The cosmetic efficacy was evaluated through skin aging scores, skin laxity, skin elasticity testing and histopathology analysis. Compared to 532 nm, PDT-630 nm significantly ameliorated UVB-induced skin roughness and epidermal thickness while enhanced collagen fiber content and improved fiber arrangement, without causing 405 nm-associated scarring. Optimal results were achieved with 2% ALA at 630 nm, whereas 10% ALA induced collagen degradation. PDT using 630 nm LED light combined with 2%ALA at an energy density of 4.5 J/cm² provided an innovative and effective approach for skin anti-aging. This protocol promoted collagen remodeling to restore youthful skin structure while minimizing epidermal damage, suggesting its potential as an optimal intervention for photoaging.
Indexed as
Identifiers
41359229What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.