ArticleJournal of assisted reproduction and genetics2026
Examining the impact of denudation and ICSI timing on embryological and clinical outcomes in oocyte donation cycles.
Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate how the timing of oocyte denudation (DN) and intracytoplasmic sperm injection (ICSI) affects embryological and clinical outcomes in highly standardized oocyte donation cycles.
methodsThis retrospective cohort study included 1538 donor stimulation cycles from a single IVF center between January 2019 and July 2023. Timing intervals between human chorionic gonadotropin (hCG) administration, oocyte pick-up (OPU), DN, and ICSI were recorded. Outcomes included oocyte maturation (MII rate), fertilization, embryo quality, and clinical results. Statistical analyses included linear and logistic regression models, and chi-square tests, adjusting for donor and recipient age and BMI.
resultsLonger hCG-DN intervals (> 39 h) were significantly associated with increased MII rates and decreased proportions of MI and discarded oocytes (P < 0.05). However, hCG-DN timing had no effect on fertilization rates, embryo quality, or pregnancy outcomes. Shorter DN-ICSI intervals (< 90 min) were associated with a higher proportion of top-quality blastocysts and fewer medium-quality embryos (P < 0.05). DN-ICSI timing did not influence clinical outcomes. Recipient BMI was the strongest predictor of pregnancy, clinical pregnancy, and live birth (P < 0.001).
conclusionsExtended incubation prior to denudation improves oocyte maturation but does not affect fertilization or pregnancy. Short DN-ICSI intervals favor top-quality blastocyst formation without altering clinical results. Recipient BMI significantly impacts reproductive success. These findings support timing optimization in ART and highlight the influence of patient-specific factors.
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