Evidence map›Paper›PMID 41359198›Full record

ArticlePituitary2025

Brain injury biomarkers and intraoperative hypotension: associations with pituitary hormone deficiency following transsphenoidal endoscopic surgery for non-functioning pituitary adenomas.

Martin Thorsson, P Trimpou, M Asztély, T Hallén, V Hantelius, K Blennow, H Zetterberg, G Johannsson, J Oras, T Skoglund

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In one paragraph

Article in Pituitary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martin ThorssonDepartment of Anesthesiology and Intensive Care, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. martin.thorsson@gu.se.ORCID http://orcid.org/0000-0001-5840-1956
P TrimpouDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
M AsztélyNorthern Älvsborg County Hospital, Trollhättan, Region Västra Götaland, Sweden.
T HallénDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
V HanteliusDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
K BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
H ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
G JohannssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
J OrasDepartment of Anesthesiology and Intensive Care, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
T SkoglundDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFactors related to the development of new pituitary hormone deficiencies following transsphenoidal surgery for non-functioning pituitary adenomas are multifactorial and remain poorly understood. We explored associations with brain injury biomarkers and investigated intraoperative hypotension (IOH) as a potential mediator.

methodsThis prospective study included 100 patients undergoing endoscopic transsphenoidal surgery. Two individual outcomes at 12-months postsurgery were analysed: new anterior pituitary hormone deficiency (APH-D) and new arginine vasopressin deficiency (AVP-D). Plasma concentrations of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and tau were measured preoperatively and on postoperative days 1 and 5. IOH was assessed using two definitions: duration below an absolute MAP threshold of 65 mmHg and duration below a relative threshold of 20% below preoperative MAP. Associations between new deficiency and biomarkers were assessed using mixed-effects models, and associations with IOH were evaluated using the Mann-Whitney U test.

resultsElevated postoperative GFAP, NfL, and tau were associated with new APH-D, with GFAP also linked to new AVP-D. Patients who experienced new APH-D demonstrated longer durations of relative IOH (median [IQR] 155 min [54-216] vs. 82 min [20-154]; p = 0.03). There was no difference in relative or absolute IOH for those with new AVP-D.

conclusionElevated postoperative plasma GFAP, NfL, and tau might indicate increased risk of long-term postoperative pituitary hormone deficiency. Relative IOH may also contribute to these deficiencies.

Indexed as

AdenomaBrain InjuriesHypopituitarismHypotensionPituitary HormonesPituitary NeoplasmsAdultAgedBiomarkersEndoscopyFemaleGlial Fibrillary Acidic ProteinHumansMaleMiddle AgedNeurofilament ProteinsBiomarkersGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsPituitary Hormonestau ProteinsGlial fibrillary acidic proteinHypotensionNeurofilament proteinPituitary neoplasmsPostoperative complicationsTau protein

Identifiers

PMID41359198
PMCPMC12686086

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.