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ArticleEuropean archives of psychiatry and clinical neuroscience2026

Impact of adverse childhood experiences on youth non-suicidal self-injury: the mediating role of rumination.

Ciqing Bao, Haowen Zou, Qiaoyang Zhang, Yi Xia, Xiaoqin Wang, Shui Tian, Qing Lu, Zhijian Yao

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Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Ciqing Bao *Behavioral Medicine Department, Wenzhou Seventh People's Hospital, Wenzhou Medical Univeristy, Wenzhou, 325000, China.
Haowen Zou *Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Qiaoyang ZhangDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Yi XiaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Xiaoqin WangDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Shui TianDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China.
Qing LuSchool of Biological Sciences & Medical Engineering, Southeast University, Nanjing, 210096, China. luq@seu.edu.cn.
Zhijian YaoDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China. zjyao@nju.edu.cn.ORCID http://orcid.org/0000-0001-6255-5771

Funding

Jiangsu Provincial Key Research and Development Program BE2019675, BE2023667Jiangsu Provincial Natural Science Youth Fund BK20230154,BK20241120Jiangsu Psychiatric Medical Innovation Center CXZX202226National Natural Science Foundation of China 82151315,82271568,82101573,82301718,82401788the Key Project of Science and Technology Innovation for Social Development in Suzhou 2022SS04the science project from Changzhou Medical Center, Nanjing Medical University CMCB202411Zhejiang Provincial Natural Science Youth Fund LQN25H090001
6 · The paper itself

Abstract

Adverse childhood experiences and rumination are both risk factors for non-suicidal self-injury (NSSI) in depression. However, the interaction among these three factors has not been well researched. This study aimed to investigate the potential mediating role of rumination between adverse childhood experiences and NSSI frequency. To this end, 276 young patients aged 15–30 years with major depressive disorder (MDD) were recruited as the research subjects. General demographic scales and clinical scales were used to assess adverse childhood experiences, rumination, levels of anxiety and depression, as well as the frequency of NSSI. Based on DSM-5 diagnostic criteria for NSSI, MDD patients were divided into two groups: the NSSI + group (n = 134) and the NSSI- group (n = 142). Mediation analysis was employed to examine the mediating role of rumination in the relationship between adverse childhood experiences and NSSI frequency. The NSSI + group exhibited higher adverse childhood experiences, rumination scores and anxiety/depression levels than the NSSI − group (all p < 0.05). After adjusting for demographic covariates, adverse childhood experiences and different types of rumination (depression related, brooding and reflection) were positively linked to NSSI frequency over three time periods (past month/past 6 months/past year). Additionally, the depression related and brooding subtypes of rumination mediate the relationship between adverse childhood experiences and NSSI frequency. Thus, this study indicates an association between adverse childhood experiences, rumination, and NSSI. These findings suggest that heightened awareness of childhood experiences, combined with interventions targeting rumination, may help reduce the risk of NSSI.

Indexed as

Adverse Childhood ExperiencesAnxietyMajor Depressive DisorderRumination, CognitiveSelf-Injurious BehaviorAdolescentAdultFemaleHumansMaleYoung AdultACEDepressionRuminationSelf-harmYouth

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.