ArticleCellular and molecular life sciences : CMLS2025
CircEPHB4 binds to YBX1 to upregulate MRPS16 and promotes glioma progression.
Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
backgroundGlioma is the most frequently diagnosed brain tumor in adults worldwide which is associated with unfavorable prognosis and survival time. However, the understanding of glioma progression remains limited.
methodsThe cell proliferation in glioma cells were monitored by EdU incorporation and CCK-8 assays. Glioma cell invasion and migration were assessed by Transwell assay. In vivo tumorigenesis were detected by xenograft study with bioluminescence imaging. qRT-PCR, RNA FISH, IHC or western blot were used to detect circEPHB4, MRPS16, YBX1, RBBP6 and other molecules expression. The associations between YBX1 and MRPS16 mRNA, as well as between circEPHB4 and YBX1, were detected by RNA immunoprecipitation (RIP) and RNA pull-down assays. In addition, the ubiquitination of YBX1 and RBBP6-YBX1 interaction were assessed by co-immunoprecipitation (co-IP).
resultsKnockdown of circEPHB4 or MRPS16 inhibited glioma progression in vitro and in vivo. circEPHB4 promoted glioma cell proliferation, migration, and invasion via increasing MRPS16 expression in vitro. At the post-transcriptional level, circEPHB4 enhanced MRPS16 mRNA stability through YBX1-mediated m
conclusioncircEPHB4 bound to YBX1 to inhibit RBBP6-mediated degradation and increase its expression, thus enhancing MRPS16 mRNA stability via m
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