ArticleMagma (New York, N.Y.)2026
Application of magnetic resonance spectroscopy (MRS) in photo-thermal therapy response of U87-MG human glioma cells with gold-coated iron oxide nanoparticles: an in vivo study.
Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
objectiveAccurate prediction of the response to nano-photothermal therapy (NPTT) requires rapid feedback from the tumor. This study utilizes proton magnetic resonance spectroscopy ( MATERIALS AND
methodsThe study was conducted on nude mice bearing U87-MG human glioma xenografts, which were assigned to distinct treatment cohorts: Au@Fe₂O₃ core-shell nanoparticles alone, laser irradiation alone, and the combined nano-photothermal therapy. The efficacy was determined by assessing post-treatment alterations in tumor volume and corresponding changes in choline and lipid metabolite signals detected via
resultsAnalysis of metabolite ratios, normalized to the water peak, demonstrated a significant post-NPTT therapeutic response. A marked decrease was observed in both the choline/creatine ratio (from 0.48 ± 0.17 to 0.24 ± 0.07) and the choline/lipid ratio (from 0.47 ± 0.23 to 0.13 ± 0.06). Notably, these metabolic alterations were evident within 24 h of the procedure. In contrast, significant reductions in tumor volume were not detectable until day 9 post-treatment.
conclusion
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Registered trials
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