Evidence map›Paper›PMID 41359074›Full record

ArticlePlant cell reports2025

CiPCS regulated by CiMYB4 enhances the tolerance of Chrysanthemum indicum to cadmium stress.

Shengyan Chen, Liran Yue, Xiaomei Yang, Bin Xia, Hongyao Li, Bin Chen, Yujia Yang, Ying Sun, Qiang Li, Junxin Yan and 1 more

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Article in Plant cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Shengyan Chen *Northeast Forestry University, Harbin, 150040, Heilongjiang, China.
Liran Yue *Northeast Forestry University, Harbin, 150040, Heilongjiang, China.
Xiaomei YangNortheast Forestry University, Harbin, 150040, Heilongjiang, China.
Bin XiaNortheast Forestry University, Harbin, 150040, Heilongjiang, China.
Hongyao LiNortheast Forestry University, Harbin, 150040, Heilongjiang, China.
Bin ChenNortheast Forestry University, Harbin, 150040, Heilongjiang, China.
Yujia YangNortheast Forestry University, Harbin, 150040, Heilongjiang, China.
Ying SunNortheast Forestry University, Harbin, 150040, Heilongjiang, China.
Qiang LiNortheast Forestry University, Harbin, 150040, Heilongjiang, China.
Junxin YanNortheast Forestry University, Harbin, 150040, Heilongjiang, China. yanjunxin@163.com.
Miao HeNortheast Forestry University, Harbin, 150040, Heilongjiang, China. hemiao@nefu.edu.cn.ORCID http://orcid.org/0000-0003-3035-4750

Funding

Natural Science Foundation of Heilongjiang Province LH2021C018
6 · The paper itself

Abstract

key messageThe transcription factor CiMYB4 enhances the tolerance of Chrysanthemum indicum to cadmium stress by regulating the CiPCS gene and promoting the synthesis of phytochelatins. Phytochelatins (PCs) are crucial for enhancing plant tolerance and detoxifying heavy metals such as cadmium (Cd). However, the functional roles and regulatory mechanisms of phytochelatin synthase (PCS), the enzyme responsible for PC synthesis in chrysanthemum, remain largely unexplored. In this study, we successfully isolated and cloned a PCS gene from Chrysanthemum indicum, designated as CiPCS. Subcellular localization analysis revealed that CiPCS is localized in both the cytoplasm and nucleus, and Cd stress significantly upregulated its expression. The overexpression of CiPCS enhanced the tolerance of C. indicum to Cd by increasing the activity of antioxidant enzymes and reducing membrane lipid peroxidation. Further analysis indicated that CiPCS is directly regulated by the transcription factor CiMYB4, promoting the synthesis and accumulation of plant chelating peptides (PCs), enhancing the chelation of Cd ions and thereby reducing the toxic effects of Cd on cells. In summary, our study elucidates the regulatory mechanism by which C. indicum responds to Cd stress.

Indexed as

AminoacyltransferasesCadmiumChrysanthemumPlant ProteinsTranscription FactorsGene Expression Regulation, PlantLipid PeroxidationPhytochelatinsPlants, Genetically ModifiedStress, PhysiologicalAminoacyltransferasesCadmiumglutathione gamma-glutamylcysteinyltransferasePhytochelatinsPlant ProteinsTranscription FactorsCadmium toleranceChrysanthemum indicumMYB transcription factorPhytochelatin synthase

Identifiers

PMID41359074

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