Evidence map›Paper›PMID 41358986›Full record

ReviewEuropean heart journal2026

Non-ST-segment elevation acute coronary syndrome: understanding the full spectrum to guide management.

Stefano Savonitto, Joseph S Alpert, Holger Thiele, Gianluca Campo, Giampaolo Niccoli, Stefano De Servi, Eugene Braunwald, Christopher B Granger

Abstract readReview
In one paragraph

Review in European heart journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stefano SavonittoDivision of Cardiology, Manzoni Hospital, Via Dell'Eremo 9/1123900, Lecco, Italy.ORCID 0000-0003-1216-0784
Joseph S AlpertUniversity of Arizona College of Medicine, Tucson, Arizona, USA.
Holger ThieleDepartment of Internal Medicine/Cardiology and Leipzig Heart Science, Heart Center Leipzig at Leipzig University, Leipzig, Germany.ORCID 0000-0002-0169-998X
Gianluca CampoCardiology Unit, Azienda Ospedaliero Universitaria di Ferrara, Cona, Ferrara, Italy.
Giampaolo NiccoliDivision of Cardiology, University of Parma, Parma University Hospital, Parma, Italy.
Stefano De ServiDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Eugene BraunwaldTIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Hale Building, Suite 7022, 60 Fenwood Road, Boston, MA 02115, USA.ORCID 0000-0002-3472-626X
Christopher B GrangerDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-0045-3291

Funding

Alnylam PharmaceuticalsAmgenBoehringer IngelheimBristol Myers SquibbJanssen PharmaceuticalsNHLBINovartisPfizerPhilips
6 · The paper itself

Abstract

Acute coronary syndromes are caused by obstructive coronary thrombosis complicating myocardial ischaemic disease and are dichotomously classified according to their electrocardiographic presentation as ST-segment elevation myocardial infraction or non-ST-segment elevation acute coronary syndrome, either without or with elevated myocardial necrosis markers. Initial diagnosis and risk stratification are reliably guided by symptoms, electrocardiographic changes, and troponin elevation and require exclusion of alternative conditions, such as Type 2 myocardial infarction and myocardial injury due to systemic conditions. Timely coronary angiography is a key component of the initial diagnosis to assess the presence of occlusive coronary artery disease, rather than an myocardial infarction with non-occluded coronary arteries, and the suitability for revascularization. While clinical trials with randomization prior to angiography have shown reduction in recurrent myocardial infarction and urgent revascularization with a neutral effect on mortality from an early invasive approach, increased revascularization rates have been systematically associated with reduced mortality in registries and administrative databases. Complete revascularization in patients with multivessel disease has been shown to reduce mortality compared with culprit-only revascularization. The safety of this approach has been shown even in fragile, elderly, and multimorbid patients. Post-acute treatment should be focused on patient-tailored antithrombotic therapy and disease-modifying secondary prevention approaches. This review describes the complex spectrum of non-ST-segment elevation acute coronary syndrome and the importance of complete clinical and coronary angiographic assessment for optimal patient-centred treatment.

Indexed as

Acute Coronary SyndromeNon-ST Elevated Myocardial InfarctionCoronary AngiographyElectrocardiographyHumansMyocardial RevascularizationPercutaneous Coronary InterventionRisk AssessmentCoronary angiographyCoronary revascularizationMyocardial infarctionNon-ST-segment elevation acute coronary syndrome

Identifiers

PMID41358986
PMCPMC12831189

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.