Evidence map›Paper›PMID 41358935›Full record

ArticleJournal of drug targeting2026

ICAM-1 targeting of nanocarriers in a human blood-brain-barrier-on-a-chip complements

Marco Vigo, Sujey Palma-Florez, Rita Grimalt-Mirada, Marina Placci, Andrés Crespo, Marina I Giannotti, Anna Lagunas, Mònica Mir, Josep Samitier, Silvia Muro

Abstract read
In one paragraph

Article in Journal of drug targeting, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marco VigoInstitute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Sujey Palma-FlorezInstitute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Rita Grimalt-MiradaInstitute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Marina PlacciInstitute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Andrés CrespoInstitute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Marina I GiannottiInstitute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Anna LagunasInstitute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Mònica MirInstitute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Josep SamitierInstitute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Silvia MuroInstitute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.

Funding

Targeted replacement of defective lysosomal enzymes in the lung and brainR01HL098416 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI MURO, SILVIA · 2010 to 2020
$3.3M
NHLBI NIH HHS R01 HL098416
6 · The paper itself

Abstract

Targeting therapeutic nanocarriers (NCs) to endothelial receptors favours transport across the blood-brain barrier (BBB), a main obstacle to access the brain. While these strategies compel validation in animals, quantitative sub-cellular resolution is non-viable

Indexed as

Blood-Brain BarrierBrainDrug CarriersDrug Delivery SystemsIntercellular Adhesion Molecule-1NanoparticlesAnimalsAstrocytesBiological TransportEndothelial CellsHumansLab-On-A-Chip DevicesMicrophysiological SystemsPericytesDrug CarriersIntercellular Adhesion Molecule-1Blood-brain barrierendothelial and basolateral interactionsICAM-1 targetingorgan-on-a-chiptargeted nanocarrierstranscytosis mechanism

Identifiers

PMID41358935
PMCPMC13231930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.