Evidence map›Paper›PMID 41358904›Full record

ArticleGlycobiology2025

Editor's Choice JAAG: a JSON input file assembler for AlphaFold 3 with glycan integration.

Chin Huang, Kelley W Moremen

Abstract read
In one paragraph

Article in Glycobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chin HuangDepartment of Biochemistry and Molecular Biology, University of Georgia, 120 Green Street, Athens, GA 30602, United States.ORCID 0000-0002-4296-0400
Kelley W MoremenDepartment of Biochemistry and Molecular Biology, University of Georgia, 120 Green Street, Athens, GA 30602, United States.ORCID 0000-0003-1768-582X

Funding

U.S. National Science Foundation BioFoundry: Glycoscience Research, Education and Training 2400220U.S. National Science Foundation BioFoundry: Glycoscience Research, Education and Training BioF:GREAT NSF: 2400220
6 · The paper itself

Abstract

Standalone AlphaFold 3 (AF3) models proteins, post-translational modifications, and ligands (including glycans) from a single JSON input file. Plausible glycan stereochemistry is more consistently achieved when monosaccharides are specified as Chemical Component Dictionary (CCD) entries and connected using bondedAtomPairs (BAP) syntax. Although this approach preserves glycan stereochemistry, assembling JSON input files manually is challenging due to the diversity of monosaccharides, linkages, branching, and structural complexity. To simplify this process, we developed JAAG (JSON input file Assembler for AlphaFold 3 with Glycan integration (https://biofgreat.org/JAAG and https://github.com/chinchc/JAAG), a web-based graphical interface that streamlines AF3 JSON file creation, reduces errors, and facilitates modeling of glycans and glycan-macromolecule interactions.

Indexed as

PolysaccharidesSoftwareProtein Processing, Post-TranslationalPolysaccharidesAlphaFold 3glycan modelingglycan stereochemistryglycoprotein modelingweb tool

Identifiers

PMID41358904
PMCPMC12718408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.