Evidence map›Paper›PMID 41358837›Full record

ArticlemBio2026

Zinc starvation uncovers bacterial host-specific proteases that shape NDM adaptability in

Clarisa Parodi, Lucas Saposnik, Román A Martino, María Soledad Ramirez, Juliana Cassataro, Andrea M Smania, Robert A Bonomo, Alejandro J Vila, Lisandro J González

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Clarisa ParodiInstituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Rosario, Argentina.ORCID 0009-0005-9643-3613
Lucas SaposnikInstituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Martín, Buenos Aires, Argentina.
Román A MartinoDepartamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
María Soledad RamirezDepartment of Biological Science, Center for Applied Biotechnology Studies, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, California, USA.ORCID 0000-0002-9904-7890
Juliana CassataroInstituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Martín, Buenos Aires, Argentina.ORCID 0000-0002-7122-869X
Andrea M SmaniaDepartamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.ORCID 0000-0002-6527-7719
Robert A BonomoCWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA.ORCID 0000-0002-3299-894X
Alejandro J VilaInstituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Rosario, Argentina.ORCID 0000-0002-7978-3233
Lisandro J GonzálezInstituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Rosario, Argentina.ORCID 0000-0002-0575-1810

Funding

A Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4M
Identifying host human products responsible for natural transformation of resistance traits in Acinetobacter sppSC3GM125556 · NIGMS · CALIFORNIA STATE UNIVERSITY FULLERTON · PI RAMIREZ, MARIA SOLEDAD · 2018 to 2025
$851k
NIAID NIH HHS R01 AI100560NIGMS NIH HHS SC3 GM125556
6 · The paper itself

Abstract

Metallo-β-lactamases, particularly New Delhi metallo-β-lactamase (NDM), threaten antibiotic therapy by disseminating across diverse bacteria. The rise of NDM-producing carbapenem-resistant

Indexed as

Acinetobacter baumanniibeta-LactamasesZincAnti-Bacterial AgentsBacterial ProteinsEscherichia coliHeat-Shock ProteinsHumansPeriplasmic ProteinsSerine EndopeptidasesAnti-Bacterial AgentsBacterial Proteinsbeta-lactamase NDM-1beta-LactamasesDegP proteaseHeat-Shock ProteinsPeriplasmic ProteinsSerine EndopeptidasesZincAcinetobacter baumanniiantimicrobial resistanceNDMperiplasmic proteostasiszinc starvation

Identifiers

PMID41358837
PMCPMC12802154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.