Evidence map›Paper›PMID 41358814›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026

Simultaneous Grafting of 3,4,5-Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors.

Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto-Fabregat, Roberta Marchetti and 1 more

Abstract read
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In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria Giulia DavighiDepartment of Chemistry (DICUS), University of Florence, Sesto F.no (FI), Italy.ORCID https://orcid.org/0000-0003-1788-567X
Francesca ClementeDepartment of Chemistry (DICUS), University of Florence, Sesto F.no (FI), Italy.ORCID https://orcid.org/0000-0002-9899-0836
Alessio MoranoDepartment of Chemistry (DICUS), University of Florence, Sesto F.no (FI), Italy.ORCID https://orcid.org/0009-0002-1236-826X
Francesca MangiavacchiDepartment of Chemistry (DICUS), University of Florence, Sesto F.no (FI), Italy.ORCID https://orcid.org/0000-0001-5344-2310
Francesca CardonaDepartment of Chemistry (DICUS), University of Florence, Sesto F.no (FI), Italy.ORCID https://orcid.org/0000-0002-6766-4624
Andrea GotiDepartment of Chemistry (DICUS), University of Florence, Sesto F.no (FI), Italy.ORCID https://orcid.org/0000-0002-1081-533X
Paolo PaoliDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Firenze, Italy.ORCID https://orcid.org/0000-0001-6448-7266
Amelia MorroneLaboratory of Molecular Genetics of Neurometabolic Diseases, Neuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Firenze, Italy.ORCID https://orcid.org/0000-0003-2890-8179
Ferran Nieto-FabregatDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0001-9847-3030
Roberta MarchettiDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0002-7173-7099
Camilla MatassiniDepartment of Chemistry (DICUS), University of Florence, Sesto F.no (FI), Italy.ORCID https://orcid.org/0000-0002-8336-383X

Funding

MUR-Dipartimenti di Eccellenza CUP B97G22000740001MUR-Dipartimenti di Eccellenza DICUS2.0Next Generation EU - MIUR (IT) 2022FSC2FANext Generation EU - MIUR (IT) 2022N9E847Next Generation EU - MIUR (IT) CUP B53D23015340006Next Generation EU - MIUR (IT) CUP B53D23015580006Next Generation EU - MIUR (IT) - NRRP DN.155311.10.2022Next Generation EU - MIUR (IT) - NRRP PE0000006
6 · The paper itself

Abstract

Low-valency multivalent iminosugars have recently emerged as promising inhibitors of the therapeutically relevant enzyme β-glucocerebrosidase (GCase). A new synthetic strategy has been developed to simultaneously build more than one trihydroxypiperidine iminosugar unit onto a polyamine scaffold via double reductive amination (DRA) of a d-mannose derived dialdehyde. Five divalent derivatives, using both aliphatic and aromatic diamines and a trivalent compound based on an aromatic scaffold have been synthesized and evaluated as GCase inhibitors. Only oligomers with an aromatic core (26, 31, and 37) strongly inhibit GCase with IC

Indexed as

Enzyme InhibitorsImino SugarsPiperidinesAminationKineticsMolecular Docking SimulationMolecular Dynamics SimulationOxidation-Reduction3,4,5-trihydroxypiperidineEnzyme InhibitorsImino SugarsPiperidinesdouble reductive aminationenzyme inhibitionGCasemolecular recognitionmultivalent iminosugars

Identifiers

PMID41358814
PMCPMC12790318

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.