Evidence map›Paper›PMID 41358813›Full record

ArticleDevelopment (Cambridge, England)2026

Defects in nephrogenesis result in an expansion of the Foxd1+ stromal progenitor population.

Michael G Michalopulos, Yan Liu, Dinesh Ravindra Raju, John T Lafin, Yanru Ma, Dhruv Gaur, Sadiksha Khadka, Chao Xing, Andrew P McMahon, Thomas J Carroll and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Michael G MichalopulosDivision of Pediatric Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yan LiuEugene McDermott Center for Human Growth and Development , University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Dinesh Ravindra RajuEugene McDermott Center for Human Growth and Development , University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
John T LafinDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yanru MaLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Dhruv GaurDivision of Pediatric Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Sadiksha KhadkaDivision of Pediatric Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chao XingDepartment of Bioinformatics and O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Andrew P McMahonDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.
Thomas J CarrollDepartment of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Keri A DrakeDivision of Pediatric Nephrology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9355-5202

Funding

UT Southwestern O'Brien Kidney Research Core CenterP30DK079328 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MOE, ORSON W · 2007 to 2021
$16.9M
Application of Progenitor Niche Signals to Ex Vivo NephrogenesisRC2DK125960 · NIDDK · ROGOSIN INSTITUTE · PI CARROLL, THOMAS JOSEPH, CLEAVER, ONDINE B · 2021 to 2025
$7.4M
Cell Interactions in Development of the Mammalian KidneyR37DK054364 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCMAHON, ANDREW P. · 2008 to 2017
$7.0M
CELL INTERACTIONS IN DEVELOPMENT OF THE MAMMALIAN KIDNEYR01DK054364 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCMAHON, ANDREW P. · 1998 to 2022
$6.9M
Application of Progenitor Niche Signals to Ex Vivo NephrogenesisR56DK125960 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI CARROLL, THOMAS JOSEPH, CLEAVER, ONDINE B · 2020 to 2020
$530k
Wilms tumor 1 (Wt1) mutation reveals mechanisms of cell lineage crosstalk in the developing kidneyK08DK131258 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DRAKE, KERI ANNE · 2022 to 2024
$502k
Chan Zuckerberg Initiative WU-20-101NIDDK NIH HHS DK054364NIDDK NIH HHS K08 DK131258NIDDK NIH HHS K08DK131258NIDDK NIH HHS P30 DK079328NIDDK NIH HHS P30DK079328NIDDK NIH HHS R01 DK054364NIDDK NIH HHS R37 DK054364NIDDK NIH HHS R56 DK125960NIDDK NIH HHS RC2 DK125960NIDDK NIH HHS RC2DK125960University of Texas Southwestern Medical Center
6 · The paper itself

Abstract

The Foxd1+ stromal progenitor cells give rise to the majority of the renal interstitium; yet, much remains to be understood about how this self-renewing progenitor population is regulated during development. Here, we demonstrate that disruption of the nephron progenitor cell (NPC) lineage via loss of Wt1 (i.e. Six2cre;Wt1c/c) results in an expansion of Foxd1+ progenitor cells in mice. Analyses of two additional models (i.e. Wnt4-null mutants, which fail to form nephron structures similar to Six2cre;Wt1c/c kidneys, and NPC ablation via diphtheria toxin using the Six2cre;RosaDTAc/+) phenocopy the expansion in Foxd1+ cells and further confirm that mutant kidneys with defects in nephrogenesis develop an abnormal increase in the stromal progenitor population. Furthermore, single nuclei RNA-sequencing shows transcriptional changes in the Foxd1+ progenitor cells from Six2cre;Wt1c/c kidneys and identifies a distinct subcluster of the Foxd1+ stroma, which is maintained independent of signals from the nephrogenic niche in the Six2cre;RosaDTAc/+ model. Overall, these findings provide insights into the developmental regulation of the stromal progenitor population and uncover heterogeneity within the Foxd1+ cells, which undergo both cellular and molecular changes in response to defects in nephrogenesis.

Indexed as

Forkhead Transcription FactorsKidneyNephronsOrganogenesisStem CellsStromal CellsAnimalsCell LineageGene Expression Regulation, DevelopmentalMiceWnt4 ProteinWT1 ProteinsForkhead Transcription FactorsFoxd1 protein, mouseWnt4 ProteinWnt4 protein, mouseWT1 protein, mouseWT1 ProteinsFoxd1Kidney developmentMouseStromal progenitor cellsWnt4Wt1

Identifiers

PMID41358813
PMCPMC12848570

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.