Evidence map›Paper›PMID 41358788›Full record

ArticleVeterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association2026

Histopathologic Findings in Three Dogs With Metastatic Carcinoma Presenting With Bronchovascular Bundle Thickening on Computed Tomography.

Robert Wise, Maria Mulvihill, Jennifer Reetz, Bianca Pfisterer, Wilfried Mai

Abstract readCase Reports
In one paragraph

Article in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Histopathologic Findings in Three Dogs With Metastatic Carcinoma Presenting With Bronchovascular Bundle Thickening on Computed Tomography.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robert WiseDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, Section of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Maria MulvihillDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, Section of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0005-2955-9048
Jennifer ReetzDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, Section of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3039-1658
Bianca PfistererDepartment of Pathobiology, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-8810-4562
Wilfried MaiDepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, Section of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-9147-6079

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carcinoma metastasis to the lungs can occur via multiple pathways, most notably via hematogenous, lymphangitic, or aerogenous routes. Computed tomographic (CT) characteristics of these metastatic pathways can vary, with only sparse reports of bronchovascular bundle thickening (BVBT) associated with metastatic carcinoma. In this retrospective cross-sectional study, three dogs with metastatic carcinoma and BVBT on CT that had corresponding histopathological sections at the site of BVBT were reviewed. These cases showed expansion of the peribronchial/peribronchiolar interstitium with islands of neoplastic cells within the stroma and either lymphatic infiltration alone or hematogenous and lymphatic infiltration combined (lymphovascular), along with neoplastic cells in the airways and/or septal lining of the alveoli. On the basis of this study, BVBT on CT in dogs can be seen with metastatic carcinoma, associated with peribronchial/peribronchiolar lymphovascular and aerogenous metastases. Additional studies are needed to characterize each metastatic pathway and further correlate histopathological findings with CT appearance.

Indexed as

BronchiCarcinomaDog DiseasesLung NeoplasmsTomography, X-Ray ComputedAnimalsCross-Sectional StudiesDogsRetrospective Studiesaerogenous metastasislymphangitic carcinomatosisperibronchovascular thickeningpulmonary carcinomaseptal metastasis

Identifiers

PMID41358788
PMCPMC12684330

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.