Evidence map›Paper›PMID 41358742›Full record

ReviewJournal of bacteriology2026

Steering the course: targeting and exploiting surface receptors in phage therapy.

Veronica N Tran, Lori L Burrows

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Veronica N TranDepartment of Biochemistry and Biomedical Sciences, The Michael G. DeGroote Institute for Infection Disease Research, McMaster University, Hamilton, Canada.ORCID 0009-0003-9717-7282
Lori L BurrowsDepartment of Biochemistry and Biomedical Sciences, The Michael G. DeGroote Institute for Infection Disease Research, McMaster University, Hamilton, Canada.ORCID 0000-0003-0838-5040

Funding

Canada Research Chairs CRC-2021-00103CIHR PJT-169053Natural Sciences and Engineering Research Council of Canada PGS-DNatural Sciences and Engineering Research Council of Canada RGPIN-2021-04237
6 · The paper itself

Abstract

The global rise of antibiotic resistance highlights the urgent need for alternative therapeutics such as bacteriophages (phages). Phages exert selective pressure that can "steer" bacteria toward reduced pathogenicity, increased antibiotic susceptibility, or immune clearance. A receptor-focused steering strategy is especially powerful since many phage receptors are also critical for bacterial fitness and virulence. Effective therapy requires identifying these receptors during characterization and combining phages that target distinct, conserved structures to minimize resistance. We review the current state of phage steering research and highlight guidelines emphasizing receptor identification for rational, durable therapeutic design. While this review focuses on

Indexed as

Bacteriophage ReceptorsBacteriophagesPhage TherapyPseudomonas aeruginosaPseudomonas InfectionsHumansBacteriophage Receptorsbacteriophagecell surfacePseudomonas aeruginosa

Identifiers

PMID41358742
PMCPMC12826054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.