Evidence map›Paper›PMID 41358607›Full record

Trial reportPsychophysiology2025

A Randomized Clinical Trial Reveals Effects of Mindfulness and Slow Breathing on Plasma Amyloid Beta Levels.

Kaoru Nashiro, B Rael Cahn, Paul Choi, Hye Rynn J Lee, Shaakhini Satchi, Jungwon Min, Hyun Joo Yoo, Christine Cho, Noah Mercer, Lorena Sordo and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Testing effects of paced breathing on plasma Aβ and brain perivascular spaces.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2026
    Trial
  2. Trial
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Kaoru NashiroUniversity of Southern California, Los Angeles, USA.ORCID 0000-0002-8227-4712
B Rael CahnUniversity of Southern California, Los Angeles, USA.
Paul ChoiUniversity of Southern California, Los Angeles, USA.
Hye Rynn J LeeUniversity of Southern California, Los Angeles, USA.
Shaakhini SatchiUniversity of Southern California, Los Angeles, USA.
Jungwon MinUniversity of Southern California, Los Angeles, USA.
Hyun Joo YooUniversity of Southern California, Los Angeles, USA.ORCID 0000-0002-5468-8168
Christine ChoUniversity of Southern California, Los Angeles, USA.
Noah MercerUniversity of Southern California, Los Angeles, USA.
Lorena SordoUniversity of California, Irvine, USA.
Elizabeth HeadUniversity of California, Irvine, USA.
Jeiran ChoupanUniversity of Southern California, Los Angeles, USA.
Mara MatherUniversity of Southern California, Los Angeles, USA.

Funding

Effects of Resonance-Frequency Breathing on Preclinical Alzheimer’s Disease Biomarkers and CognitionR01AG080652 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2023 to 2026
$3.9M
Epstein Breakthrough Alzheimer's Research FundNIA NIH HHS R01 AG080652NIA NIH HHS R01AG080652
6 · The paper itself

Abstract

Prior research suggests that meditation may slow brain aging and reduce the risk of Alzheimer's disease (AD). However, we lack research systematically examining what aspect(s) of meditation may drive such benefits. In particular, it is unknown how breathing patterns during meditation might influence health outcomes associated with AD. In this study, we examined whether two types of mindfulness meditation practice-one with slow breathing and one with normal breathing-differently affect plasma amyloid beta (Aβ) relative to a no-intervention control group. One week of daily mindfulness practice with slow breathing decreased plasma Aβ levels whereas one week of daily mindfulness practice with normal breathing increased plasma Aβ levels. The no-intervention control group showed no changes in plasma Aβ levels. Slow breathing appears to be a factor through which meditative practices can influence pathways relevant for AD.

Indexed as

Amyloid beta-PeptidesMeditationMindfulnessRespirationAgedAlzheimer DiseaseFemaleHumansMaleMiddle AgedAmyloid beta-Peptides

Identifiers

PMID41358607
PMCPMC12683982

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.