Evidence map›Paper›PMID 41358587›Full record

ArticleACS infectious diseases2026

Structure, Function, and Inhibition of Adenylosuccinate Lyase (ADSL) from

Vigyasa Singh, Devi Jaganathan, Jamie Corro, Ke Chen, Subodh Kumar Samrat, Ran Zhang, Mengjiao Ma, Kevin P Battaile, Zhong Li, Qing-Yu Zhang and 3 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vigyasa SinghDepartment of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel Street, Tucson, Arizona 85721-0207, United States.
Devi JaganathanDepartment of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel Street, Tucson, Arizona 85721-0207, United States.ORCID 0009-0000-3374-2391
Jamie CorroDivision of Genetics, New York State Department of Health, Wadsworth Center, Albany, New York 12237, United States.
Ke ChenDepartment of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel Street, Tucson, Arizona 85721-0207, United States.
Subodh Kumar SamratDepartment of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel Street, Tucson, Arizona 85721-0207, United States.
Ran ZhangDepartment of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel Street, Tucson, Arizona 85721-0207, United States.
Mengjiao MaDepartment of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel Street, Tucson, Arizona 85721-0207, United States.
Kevin P BattaileNew York Structural Biology Center, New York, New York 10027, United States.ORCID 0000-0003-0833-3259
Zhong LiDepartment of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel Street, Tucson, Arizona 85721-0207, United States.
Qing-Yu ZhangDepartment of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel Street, Tucson, Arizona 85721-0207, United States.
Rui XiongDepartment of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel Street, Tucson, Arizona 85721-0207, United States.
Anil K OjhaDivision of Genetics, New York State Department of Health, Wadsworth Center, Albany, New York 12237, United States.ORCID 0000-0001-5940-2643
Hongmin LiDepartment of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel Street, Tucson, Arizona 85721-0207, United States.ORCID 0000-0002-8684-5308

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
High throughput screening assays to identify chemical probes targeting Hectd3, an E3 ubiquitin ligase implicated in multiple sclerosisR01AI161845 · NIAID · UNIVERSITY OF ARIZONA · PI AVRAM, DORINA, LI, HONGMIN · 2021 to 2025
$3.9M
Alternative Ribosomes & Antibiotic Tolerance in MycobacteriaR01AI132422 · NIAID · WADSWORTH CENTER · PI RAJENDRA K AGRAWAL, Anil Kumar Ojha · 2017 to 2026
$3.8M
Development of Inhibitors Targeting Flavivirus MethyltransferaseR01AI175435 · NIAID · UNIVERSITY OF ARIZONA · PI HONGMIN LI · 2023 to 2026
$3.1M
An Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-IIS10OD030394 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI BATTAILE, KEVIN P · 2021 to 2021
$1.8M
Development of Inhibitors Against SARS CoV-2 NSP16 MethyltransferaseR41AI177149 · NIAID · LYCHEE BIOSCIENCE LLC · PI LI, HONGMIN · 2024 to 2025
$600k
NIAID NIH HHS R01 AI132422NIAID NIH HHS R01 AI161845NIAID NIH HHS R01 AI175435NIAID NIH HHS R41 AI177149NIGMS NIH HHS P30 GM133894NIH HHS S10 OD030394
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adenylosuccinate LyaseAntitubercular AgentsBacterial ProteinsEnzyme InhibitorsMycobacterium tuberculosisHigh-Throughput Screening AssaysHumansKineticsModels, MolecularAdenylosuccinate LyaseAntitubercular AgentsBacterial ProteinsEnzyme Inhibitorsadenylosuccinate lyase (ADSL)crystal structurehigh throughput screening assaysinhibitorMycobacterium tuberculosisPPDKPurB

Identifiers

PMID41358587
PMCPMC12812255

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.