Evidence map›Paper›PMID 41358483›Full record

ArticleJournal of medicinal chemistry2025

Design, Synthesis, and Biological Evaluation of Highly Potent Boronic Acid (Boronate Ester)-Bearing Heteroaryldihydropyrimidine Derivatives as HBV Capsid Assembly Modulators.

Yu Jin, Yang Sun, Shujie Zhao, Shuo Wang, Yutong Dou, Kai Wang, Qilan Li, John E Tavis, Zhuanchang Wu, Peng Zhan and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yu JinDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P. R. China.
Yang SunKey Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province and Dept. Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan 250012, Shandong, P. R. China.ORCID 0009-0004-9501-3599
Shujie ZhaoDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P. R. China.
Shuo WangDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P. R. China.
Yutong DouKey Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province and Dept. Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan 250012, Shandong, P. R. China.
Kai WangKey Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province and Dept. Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan 250012, Shandong, P. R. China.
Qilan LiDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100, S. Grand Boulevard, St. Louis, Missouri 63104, United States.
John E TavisDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100, S. Grand Boulevard, St. Louis, Missouri 63104, United States.
Zhuanchang WuKey Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province and Dept. Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan 250012, Shandong, P. R. China.
Peng ZhanDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P. R. China.ORCID 0000-0002-9675-6026
Xinyong LiuDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P. R. China.ORCID 0000-0002-7302-2214

Funding

Lead optimization of Hepatitis B Virus ribonuclease H inhibitorsR01AI150610 · NIAID · SAINT LOUIS UNIVERSITY · PI MEYERS, MARVIN J, TAVIS, JOHN E · 2021 to 2025
$3.3M
NIAID NIH HHS R01 AI150610
6 · The paper itself

Abstract

Hepatitis B virus (HBV) capsid assembly modulators (CAMs) are a new class of specific antiviral agents that interfere with the capsid assembly process to exert antiviral effects. In this study, we rationally designed and chemically synthesized a series of novel boronic acid (boronate ester)-bearing heteroaryldihydropyrimidine (HAP) derivatives based on a multisite-binding strategy in the solvent-exposed region. Among them,

Indexed as

Antiviral AgentsBoronic AcidsCapsidDrug DesignHepatitis B virusPyrimidinesVirus AssemblyAnimalsCapsid ProteinsEstersHumansMiceStructure-Activity RelationshipVirus ReplicationAntiviral AgentsBoronic AcidsCapsid ProteinsEstersPyrimidines

Identifiers

PMID41358483
PMCPMC13006845

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.