Evidence map›Paper›PMID 41358374›Full record

ReviewNanoscale2026

Gold nanoparticle transport across tumour-associated biological barriers:

Christina Christodoulou, Alexander J MacRobert, Marilena Loizidou, Bala Ramesh, Kate Ricketts, Christopher Thrasivoulou, Gavin Jell, Hirak K Patra

Abstract readReview
In one paragraph

Review in Nanoscale, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christina ChristodoulouDepartment of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London, Royal Free Hospital, Pond St, London NW3 2QG, UK. hirak.patra@ucl.ac.uk.ORCID http://orcid.org/0000-0001-6136-4113
Alexander J MacRobertDepartment of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London, Royal Free Hospital, Pond St, London NW3 2QG, UK. hirak.patra@ucl.ac.uk.
Marilena LoizidouDepartment of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London, Royal Free Hospital, Pond St, London NW3 2QG, UK. hirak.patra@ucl.ac.uk.
Bala RameshDepartment of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London, Royal Free Hospital, Pond St, London NW3 2QG, UK. hirak.patra@ucl.ac.uk.
Kate RickettsDivision of Surgery and Interventional Science, University College London, Charles Bell House, 43-45 Foley Street, London W1 W 7JN, UK.
Christopher ThrasivoulouDivision of Bioscience, Centre for Cell & Molecular Dynamics, University College London, 21 University Street, London WC1E 6DE, UK.ORCID http://orcid.org/0000-0001-9425-8624
Gavin JellDepartment of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London, Royal Free Hospital, Pond St, London NW3 2QG, UK. hirak.patra@ucl.ac.uk.
Hirak K PatraDepartment of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London, Royal Free Hospital, Pond St, London NW3 2QG, UK. hirak.patra@ucl.ac.uk.ORCID http://orcid.org/0000-0002-6142-5489

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gold nanoparticles have long been explored for their potential in medical diagnostics, drug delivery, and imaging, particularly in oncology. However, successful translation to clinical applications requires a deep understanding of their biomolecular interactions and transport mechanisms across cellular barriers and within cells. In this review, we examine the current understanding of the journey of gold nanoparticles from systemic administration to tumour infiltration. Specific focus is placed on the biological barriers crossed and the mechanisms involved in traversing those barriers, including active and selective transport pathways, like transcytosis, increasingly recognised as critical for nanoparticle translocation across endothelial and tumour barriers. We stratify the nanoparticle journey into smaller stages and critically discuss the most relevant

Indexed as

GoldMetal NanoparticlesNeoplasmsAnimalsBiological TransportHumansGold

Identifiers

PMID41358374
PMCPMC12683651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.