ArticlemedRxiv : the preprint server for health sciences2025
Longitudinal functional network connectivity changes across the clinical stages of
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionIntrinsic functional connectivity network abnormalities in
methodsWe analyzed task-free fMRI and structural MRI data in 36 asymptomatic (aSxC9), 17 prodromal (proC9), and 29 symptomatic (SxC9) carriers, and 107 healthy controls (HC). Functional networks previously found altered in
resultsDespite lacking detectable gray matter decline, aSxC9 and SxC9 showed longitudinal connectivity changes within specific networks. In aSxC9, connectivity changes correlated with baseline NfL. In proC9 and SxC9, changes in connectivity and gray matter were associated with baseline NfL and symptom severity. DISCUSSION: Highlights: - Stage-specific longitudinal connectivity changes were detected in Research in Context: Systematic review: The authors conducted a systematic review using major databases (e.g., PubMed and Google Scholar). While cross-sectional studies have investigated functional connectivity patterns in
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